Structure information

B2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7F2O

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

PUBLICATION DATE

Oct. 13, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
bradykinin W113 2.60x60 TM2 hydrophobic
bradykinin F121 ECL1 aromatic (face-to-edge)
bradykinin L141 3.36x36 TM3 hydrophobic
bradykinin Y201 ECL2 polar (charge-assisted hydrogen bond)
bradykinin E204 ECL2 polar (charge-assisted hydrogen bond)
bradykinin E204 ECL2 polar (charge-charge)
bradykinin A210 ECL2 hydrophobic
bradykinin C211 45.50x50 ECL2 polar (hydrogen bond with backbone)
bradykinin V212 45.51x51 ECL2 hydrophobic
bradykinin I213 45.52x52 ECL2 polar (hydrogen bond with backbone)
bradykinin F286 6.51x51 TM6 aromatic (face-to-edge)
bradykinin D293 6.58x58 TM6 polar (charge-assisted hydrogen bond)
bradykinin D293 6.58x58 TM6 polar (charge-charge)
bradykinin R297 6.62x62 TM6 polar (charge-assisted hydrogen bond)
bradykinin R297 6.62x62 TM6 polar (charge-assisted hydrogen bond)
bradykinin E307 7.28x27 TM7 polar (charge-charge)
bradykinin D311 7.32x31 TM7 polar (charge-charge)
bradykinin T314 7.35x34 TM7 polar (charge-assisted hydrogen bond)
bradykinin T314 7.35x34 TM7 polar (hydrogen bond)
bradykinin S318 7.39x38 TM7 polar (hydrogen bond)
bradykinin Y322 7.43x42 TM7 aromatic (face-to-edge)

Ligands

bradykinin

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Residue Diagrams

I N E L T A L V F L V W L F P P Q I T N 1 G N L A A A D L I L A C G L P F W A I T 2 L M L F C I S S Y L N M S I I A N V V R 3 A K L Y S L V I W G C T L L L S S P M 4 T C F T I V S L P L L F G V V N L L M N T 5 L V V L L L F I I C W L P F Q I S T F L 6 L P N L C S N S Y A M F S A I Q T I V 7
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ICL1 K S S C ICL1ECL1 F D W L F ECL1ICL2 T M S M G R M R ICL2ECL2 T M K E Y S D E G H N V T A C V I S Y P ECL2ICL3 F K E ICL3ECL3 I L S ECL3N-term M F S P W K I S M F L S V R E D S V P T T A S F S A D M L N V T L Q G P T L N G T F A Q S K C P Q V E W L G N-termC-term Y Q G V C Q K G G C R S E P I Q M E N S M G T L R T S I S V E R Q I H K L Q D W A G S R Q C-term W L N T I Q P P F L W V L F V L A T L E N I F V L S V F C L H T V A E I Y L G N L A A A D L I L A C G L P F W A I T I S N N G E T L C R V V N A I I S M N L Y S S I C F L M L V S I D R Y L A L V K G V R W A K L Y S L V I W G C T L L L S S P M L V F R S L I W E V F T N M L L N V V G F L L P L S V I T F C T M Q I M Q V L R N N E M Q K I Q T E R R A T V L V L V V L L L F I I C W L P F Q I S T F L D T L H R L G S C Q D E R I I D V I T Q I A S F M A Y S N S C L N P L V Y V I V G K R S W E F R K K V
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Residue Table


GPCRdb(A)
GPCRdb(A)
B2 receptor
TM2
2x60 2.60x60 W113
TM3
3x36 3.36x36 L141
ECL2
45x50 45.50x50 C211
45x51 45.51x51 V212
45x52 45.52x52 I213
TM6
6x51 6.51x51 F286
6x58 6.58x58 D293
6x62 6.62x62 R297
TM7
7x27 7.28x27 E307
7x31 7.32x31 D311
7x34 7.35x34 T314
7x38 7.39x38 S318
7x42 7.43x42 Y322