Structure information

B2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7F6H

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

A

PUBLICATION DATE

Jan. 5, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
bradykinin W113 2.60x60 TM2 hydrophobic
bradykinin F121 ECL1 hydrophobic
bradykinin I137 3.32x32 TM3 hydrophobic
bradykinin L141 3.36x36 TM3 hydrophobic
bradykinin R196 4.64x65 TM4 polar (charge-assisted hydrogen bond)
bradykinin Y201 ECL2 aromatic (face-to-edge)
bradykinin Y201 ECL2 Van der Waals
bradykinin A210 ECL2 hydrophobic
bradykinin V212 45.51x51 ECL2 Van der Waals
bradykinin V212 45.51x51 ECL2 hydrophobic
bradykinin I213 45.52x52 ECL2 Van der Waals
bradykinin I213 45.52x52 ECL2 polar (hydrogen bond with backbone)
bradykinin Y215 ECL2 hydrophobic
bradykinin L228 5.42x43 TM5 Van der Waals
bradykinin L228 5.42x43 TM5 hydrophobic
bradykinin F286 6.51x51 TM6 aromatic (face-to-edge)
bradykinin F286 6.51x51 TM6 Van der Waals
bradykinin S289 6.54x54 TM6 Van der Waals
bradykinin T290 6.55x55 TM6 Van der Waals
bradykinin T290 6.55x55 TM6 polar (hydrogen bond)
bradykinin D293 6.58x58 TM6 polar (charge-assisted hydrogen bond)
bradykinin R297 6.62x62 TM6 polar (charge-assisted hydrogen bond)
bradykinin D311 7.32x31 TM7 polar (charge-assisted hydrogen bond)
bradykinin Q315 7.36x35 TM7 Van der Waals
bradykinin S318 7.39x38 TM7 Van der Waals
bradykinin F319 7.40x39 TM7 hydrophobic
bradykinin A321 7.42x41 TM7 Van der Waals
bradykinin Y322 7.43x42 TM7 aromatic (face-to-edge)
bradykinin Y322 7.43x42 TM7 Van der Waals

Ligands

bradykinin

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Residue Diagrams

I N E L T A L V F L V W L F P P Q I T N 1 G N L A A A D L I L A C G L P F W A I T 2 L M L F C I S S Y L N M S I I A N V V R 3 A K L Y S L V I W G C T L L L S S P M 4 T C F T I V S L P L L F G V V N L L M N T 5 L V V L L L F I I C W L P F Q I S T F L 6 L P N L C S N S Y A M F S A I Q T I V 7
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ICL1 K S S C ICL1ECL1 F D W L F ECL1ICL2 T M S M G R M R ICL2ECL2 T M K E Y S D E G H N V T A C V I S Y P ECL2ICL3 F K E ICL3ECL3 I L S ECL3N-term M F S P W K I S M F L S V R E D S V P T T A S F S A D M L N V T L Q G P T L N G T F A Q S K C P Q V E W L G N-termC-term Y Q G V C Q K G G C R S E P I Q M E N S M G T L R T S I S V E R Q I H K L Q D W A G S R Q C-term W L N T I Q P P F L W V L F V L A T L E N I F V L S V F C L H T V A E I Y L G N L A A A D L I L A C G L P F W A I T I S N N G E T L C R V V N A I I S M N L Y S S I C F L M L V S I D R Y L A L V K G V R W A K L Y S L V I W G C T L L L S S P M L V F R S L I W E V F T N M L L N V V G F L L P L S V I T F C T M Q I M Q V L R N N E M Q K I Q T E R R A T V L V L V V L L L F I I C W L P F Q I S T F L D T L H R L G S C Q D E R I I D V I T Q I A S F M A Y S N S C L N P L V Y V I V G K R S W E F R K K V
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Residue Table


GPCRdb(A)
GPCRdb(A)
B2 receptor
TM2
2x60 2.60x60 W113
TM3
3x32 3.32x32 I137
3x36 3.36x36 L141
TM4
4x65 4.64x65 R196
ECL2
45x51 45.51x51 V212
45x52 45.52x52 I213
TM5
5x43 5.42x43 L228
TM6
6x51 6.51x51 F286
6x54 6.54x54 S289
6x55 6.55x55 T290
6x58 6.58x58 D293
6x62 6.62x62 R297
TM7
7x31 7.32x31 D311
7x35 7.36x35 Q315
7x38 7.39x38 S318
7x39 7.40x39 F319
7x41 7.42x41 A321
7x42 7.43x42 Y322