Structure information

ghrelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7F83

SPECIES

Homo sapiens

RESOLUTION

2.940

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-022-27975-9

PUBLICATION DATE

Jan. 19, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PF-05190457 C95 2.56x56 TM2 hydrophobic
PF-05190457 L98 2.59x59 TM2 hydrophobic
PF-05190457 D99 2.60x60 TM2 polar (charge-assisted hydrogen bond)
PF-05190457 R102 2.63x63 TM2 Van der Waals
PF-05190457 G112 3.21x21 TM3 Van der Waals
PF-05190457 L115 3.24x24 TM3 hydrophobic
PF-05190457 L115 3.24x24 TM3 Van der Waals
PF-05190457 C116 3.25x25 TM3 Van der Waals
PF-05190457 C116 3.25x25 TM3 hydrophobic
PF-05190457 F119 3.28x28 TM3 Van der Waals
PF-05190457 F119 3.28x28 TM3 hydrophobic
PF-05190457 Q120 3.29x29 TM3 Van der Waals
PF-05190457 S123 3.32x32 TM3 Van der Waals
PF-05190457 T127 3.36x36 TM3 Van der Waals
PF-05190457 F272 6.44x44 TM6 hydrophobic
PF-05190457 F272 6.44x44 TM6 Van der Waals
PF-05190457 C275 6.47x47 TM6 Van der Waals
PF-05190457 C275 6.47x47 TM6 polar (hydrogen bond with backbone)
PF-05190457 W276 6.48x48 TM6 polar (hydrogen bond)
PF-05190457 W276 6.48x48 TM6 aromatic (face-to-face)
PF-05190457 F279 6.51x51 TM6 hydrophobic
PF-05190457 F279 6.51x51 TM6 Van der Waals
PF-05190457 S308 7.38x37 TM7 Van der Waals
PF-05190457 S308 7.38x37 TM7 polar (hydrogen bond with backbone)
PF-05190457 S308 7.38x37 TM7 polar (hydrogen bond)
PF-05190457 F309 7.39x38 TM7 polar (hydrogen bond with backbone)
PF-05190457 F309 7.39x38 TM7 Van der Waals
PF-05190457 F312 7.42x41 TM7 Van der Waals
PF-05190457 F312 7.42x41 TM7 hydrophobic
PF-05190457 S315 7.45x45 TM7 Van der Waals

Ligands

PF-05190457

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Residue Diagrams

L N G A I G V V F L A V C T A T V G A L 1 S S M A F S D L L I F L C M P L D L V R 2 A T I T L V T A Y T C S E S V F Q F L K 3 V K L V I F V I W A V A F C S A G P I 4 Y L V T L C F V P L F F F I S S V W V M 5 A V V V F A F I L C W L P F H V G R Y L 6 I P N I A A S L Y F L V F S V L N C Y 7
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ICL1 R E L R ICL1ECL1 R P W N F ECL1ICL2 P L R A K V V V ICL2ECL2 G V E H E N G T D P W D T N E C R P T E F A V R S ECL2ICL3 A V V G A ICL3ECL3 P G S ECL3N-term M W N A T P S E E P G F N L T L A D L D W D A S P G N D S L G D E L L Q L F N-termC-term F S Q R K L S T L K D E S S R A W T E S S I N T C-term P A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q Y G D L L C K L F Q F V S E S C T Y A T V L T I T A L S V E R Y F A I C F T K G R V K L V I F V I W A V A F C S A G P I F V L V G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R R R R G D S L R D Q N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S F E L E I A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K V F R E P Y R V A L L G F
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Residue Table


GPCRdb(A)
GPCRdb(A)
ghrelin receptor
TM2
2x56 2.56x56 C95
2x59 2.59x59 L98
2x60 2.60x60 D99
2x63 2.63x63 R102
TM3
3x21 3.21x21 G112
3x24 3.24x24 L115
3x25 3.25x25 C116
3x28 3.28x28 F119
3x29 3.29x29 Q120
3x32 3.32x32 S123
3x36 3.36x36 T127
TM6
6x44 6.44x44 F272
6x47 6.47x47 C275
6x48 6.48x48 W276
6x51 6.51x51 F279
TM7
7x37 7.38x37 S308
7x38 7.39x38 F309
7x41 7.42x41 F312
7x45 7.45x45 S315