PDB
7FIH
Resolution
3.2 Å
Released
Sept. 29, 2021
Receptor
LH
Class
A
Species
Homo sapiens
Ligands
Function
Chorionic gonadotropin alpha subunit
Agonist
Org43553
Allosteric agonist
Chorionic gonadotropin beta subunit
Agonist
Reference
10.1038/S41586-021-03924-2
Chorionic gonadotropin alpha subunit Org43553 Chorionic gonadotropin beta subunit

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Ligand Amino Acid Generic Number Segment Interaction Type
Chorionic gonadotropin beta subunit Y58 N-term polar (hydrogen bond)
Chorionic gonadotropin alpha subunit K77 N-term Van der Waals
Chorionic gonadotropin beta subunit E79 N-term Van der Waals
Chorionic gonadotropin alpha subunit Q82 N-term hydrophobic
Chorionic gonadotropin beta subunit Q82 N-term Van der Waals
Chorionic gonadotropin alpha subunit I83 N-term Van der Waals
Chorionic gonadotropin alpha subunit D84 N-term hydrophobic
Chorionic gonadotropin alpha subunit E102 N-term polar (hydrogen bond)
Chorionic gonadotropin beta subunit Q106 N-term polar (hydrogen bond)
Chorionic gonadotropin alpha subunit N107 N-term hydrophobic
Chorionic gonadotropin alpha subunit K109 N-term hydrophobic
Chorionic gonadotropin alpha subunit K109 N-term polar (hydrogen bond)
Chorionic gonadotropin alpha subunit K126 N-term Van der Waals
Chorionic gonadotropin alpha subunit N132 N-term hydrophobic
Chorionic gonadotropin alpha subunit T133 N-term Van der Waals
Chorionic gonadotropin alpha subunit G134 N-term Van der Waals
Chorionic gonadotropin alpha subunit E148 N-term Van der Waals
Chorionic gonadotropin alpha subunit S149 N-term polar (hydrogen bond)
Chorionic gonadotropin beta subunit N150 N-term Van der Waals
Chorionic gonadotropin alpha subunit N150 N-term Van der Waals
Chorionic gonadotropin alpha subunit I152 N-term Van der Waals
Chorionic gonadotropin alpha subunit E154 N-term polar (charge-charge)
Chorionic gonadotropin alpha subunit E154 N-term polar (hydrogen bond)
Chorionic gonadotropin beta subunit D157 N-term polar (hydrogen bond)
Chorionic gonadotropin beta subunit D157 N-term polar (charge-charge)
Chorionic gonadotropin alpha subunit L159 N-term hydrophobic
Chorionic gonadotropin alpha subunit T178 N-term Van der Waals
Chorionic gonadotropin alpha subunit K180 N-term Van der Waals
Chorionic gonadotropin beta subunit Y182 N-term Van der Waals
Chorionic gonadotropin alpha subunit Y182 N-term Van der Waals
Chorionic gonadotropin beta subunit G183 N-term Van der Waals
Chorionic gonadotropin beta subunit T200 N-term Van der Waals
Chorionic gonadotropin alpha subunit K205 N-term polar (charge-charge)
Chorionic gonadotropin alpha subunit K205 N-term polar (hydrogen bond)
Chorionic gonadotropin beta subunit E206 N-term polar (hydrogen bond)
Chorionic gonadotropin beta subunit E206 N-term polar (charge-charge)
Chorionic gonadotropin beta subunit K225 N-term Van der Waals
Chorionic gonadotropin beta subunit R247 N-term Van der Waals
Chorionic gonadotropin alpha subunit Y331 N-term Van der Waals
Org43553 A349 N-term Van der Waals
Org43553 F350 N-term Van der Waals
Org43553 V447 3.33x33 TM3 hydrophobic
Org43553 S450 3.36x36 TM3 Van der Waals
Org43553 E451 3.37x37 TM3 Van der Waals
Org43553 F515 45.51x51 ECL2 hydrophobic
Org43553 P516 45.52x52 ECL2 hydrophobic
Org43553 M517 ECL2 hydrophobic
Org43553 V519 ECL2 hydrophobic
Org43553 I528 5.40x40 TM5 hydrophobic
Org43553 I531 5.43x43 TM5 hydrophobic
Org43553 F588 6.54x54 TM6 Van der Waals
Org43553 A589 6.55x55 TM6 hydrophobic
Org43553 A592 6.58x58 TM6 hydrophobic
Org43553 A593 6.59x59 TM6 Van der Waals
Org43553 K595 6.61x61 TM6 polar (hydrogen bond)
Org43553 P597 ECL3 Van der Waals
Org43553 I599 ECL3 Van der Waals
Org43553 V601 7.31x30 TM7 Van der Waals
Org43553 S604 7.34x33 TM7 polar (hydrogen bond)
Org43553 Y612 7.42x41 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R Y K L ICL1ECL1 K G Q Y Y N H A I D W Q T ECL1ICL2 A I H L D Q K L ICL2ECL2 V S N Y M K V S I C F P M D V E ECL2ICL3 N P E L M ICL3ECL3 V P L I ECL3N-term M K Q R F S A L Q L L K L L L L L Q P P L P R A L R E A L C P E P C N C V P D G A L R C P G P T A G L T R L S L A Y L P V K V I P S Q A F R G L N E V I K I E I S Q I D S L E R I E A N A F D N L L N L S E I L I Q N T K N L R Y I E P G A F I N L P R L K Y L S I C N T G I R K F P D V T K V F S S E S N F I L E I C D N L H I T T I P G N A F Q G M N N E S V T L K L Y G N G F E E V Q S H A F N G T T L T S L E L K E N V H L E K M H N G A F R G A T G P K T L D I S S T K L Q A L P S Y G L E S I Q R L I A T S S Y S L K K L P S R E T F V N L L E A T L T Y P S H C C A F R N L P T K E Q N F S H S I S E N F S K Q C E S T V R K V N N K T L Y S S M L A E S E L S G W D Y E Y G F C L P K T P R C A P E P D A F N P C E D I M G N-termC-term G C C K R R A E L Y R R K D F S A Y T S N C K N G F T G S N K P S Q S T L K L S T L H C Q G T A L L D K T R Y T E C C-term Y D F L R V L I W L I N I L A I M G N M T V L F V L L T S T V P R F L M C N L S F A D F C M G L Y L L L I A S V D S Q T G S G C S T A G F F T V F A S E L S V Y T L T V I T L E R W H T I T Y R L R H A I L I M L G G W L F S S L I A M L P L V G T T L S Q V Y I L T I L I L N V V A F F I I C A C Y I K I Y F A V R A T N K D T K I A K K M A I L I F T D F T C M A P I S F F A I S A A F K T V T N S K V L L V L F Y P I N S C A N P F L Y A I F T K T F F L F F Q R D L L S K
Helix box plot — Download: PNG | SVG M N G M I A L I N I L W I L V R L F D Y 1 C N L S F A D F C M G L Y L L L I A S V 2 V T L T Y V S L E S A F V T F F G A T S 3 A I L I M L G G W L F S S L I A M L P L 4 Y C A C I I F F A V V N L I L I T L I Y 5 A I L I F T D F T C M A P I S F F A I S 6 F P N A C S N I P Y F L V L L V K S N 7

GPCRdb(A)
GPCRdb(A)
LH receptor
TM3
3x33 3.33x33 V447
3x36 3.36x36 S450
3x37 3.37x37 E451
ECL2
45x51 45.51x51 F515
45x52 45.52x52 P516
TM5
5x40 5.40x40 I528
5x43 5.43x43 I531
TM6
6x54 6.54x54 F588
6x55 6.55x55 A589
6x58 6.58x58 A592
6x59 6.59x59 A593
6x61 6.61x61 K595
TM7
7x30 7.31x30 V601
7x33 7.34x33 S604
7x41 7.42x41 Y612