PDB
7FIN
Resolution
3.1 Å
Released
Feb. 23, 2022
Receptor
GIP
Class
B1
Species
Homo sapiens
Ligand
Peptide 20
Function
Agonist
Reference
10.1038/S41467-022-28683-0

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Ligand Amino Acid Generic Number Segment Interaction Type
Peptide 20 Q30 N-term polar (hydrogen bond with backbone)
Peptide 20 Q30 N-term Van der Waals
Peptide 20 T31 N-term Van der Waals
Peptide 20 A32 N-term Van der Waals
Peptide 20 L35 N-term hydrophobic
Peptide 20 L35 N-term Van der Waals
Peptide 20 Y36 N-term Van der Waals
Peptide 20 Y36 N-term hydrophobic
Peptide 20 W39 N-term Van der Waals
Peptide 20 W39 N-term aromatic (face-to-edge)
Peptide 20 M67 N-term Van der Waals
Peptide 20 M67 N-term hydrophobic
Peptide 20 Y68 N-term Van der Waals
Peptide 20 Y68 N-term hydrophobic
Peptide 20 Y87 N-term Van der Waals
Peptide 20 Y87 N-term hydrophobic
Peptide 20 W90 N-term Van der Waals
Peptide 20 W90 N-term hydrophobic
Peptide 20 R113 N-term polar (charge-assisted hydrogen bond)
Peptide 20 H115 N-term Van der Waals
Peptide 20 N120 N-term polar (hydrogen bond)
Peptide 20 F127 1.29x29 TM1 polar (hydrogen bond with backbone)
Peptide 20 F127 1.29x29 TM1 Van der Waals
Peptide 20 L128 1.30x30 TM1 Van der Waals
Peptide 20 R131 1.33x33 TM1 polar (charge-assisted hydrogen bond)
Peptide 20 L134 1.36x36 TM1 Van der Waals
Peptide 20 L134 1.36x36 TM1 hydrophobic
Peptide 20 E135 1.37x37 TM1 Van der Waals
Peptide 20 Q138 1.40x40 TM1 polar (hydrogen bond)
Peptide 20 Q138 1.40x40 TM1 polar (hydrogen bond)
Peptide 20 Y141 1.43x43 TM1 Van der Waals
Peptide 20 Y141 1.43x43 TM1 hydrophobic
Peptide 20 Y145 1.47x47 TM1 polar (hydrogen bond)
Peptide 20 Y145 1.47x47 TM1 polar (hydrogen bond)
Peptide 20 Y145 1.47x47 TM1 Van der Waals
Peptide 20 R183 2.60x60 TM2 Van der Waals
Peptide 20 I187 2.64x64 TM2 Van der Waals
Peptide 20 R190 2.67x67 TM2 Van der Waals
Peptide 20 P197 ECL1 hydrophobic
Peptide 20 P197 ECL1 Van der Waals
Peptide 20 P199 ECL1 hydrophobic
Peptide 20 P199 ECL1 Van der Waals
Peptide 20 V227 3.40x40 TM3 Van der Waals
Peptide 20 V227 3.40x40 TM3 hydrophobic
Peptide 20 E288 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
Peptide 20 R289 ECL2 polar (charge-assisted hydrogen bond)
Peptide 20 N290 ECL2 Van der Waals
Peptide 20 N290 ECL2 polar (hydrogen bond with backbone)
Peptide 20 W296 5.36x37 TM5 Van der Waals
Peptide 20 W296 5.36x37 TM5 hydrophobic
Peptide 20 R370 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Peptide 20 E377 7.42x41 TM7 Van der Waals
Peptide 20 I378 7.43x42 TM7 Van der Waals
Peptide 20 I378 7.43x42 TM7 hydrophobic

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ICL1 R R L H ICL1ECL1 P R P G P Y L G D Q A L A L W N ECL1ICL2 V G G S E E G ICL2ECL2 N T Q C W E R N E V ECL2ICL3 Q M ICL3ECL3 T E E Q A R ECL3N-term M T T S P I L Q L L L R L S L C G L L L Q R A E T G S K G Q T A G E L Y Q R W E R Y R R E C Q E T L A A A E P P S G L A C N G S F D M Y V C W D Y A A P N A T A R A S C P W Y L P W H H H V A A G F V L R Q C G S D G Q W G L W R D H T Q C E N P E K N-termC-term Q L P E R A F R A L P S G S G P G E V P T S R G L S S G T L P G P G N E A S R E L E S Y C C-term N E A F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F C T R N Y I H I N L F T S F M L R A A A I L S R D R L L Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R R C R D Y R L R L A R S T L T L V P L L G V H E V V F A P V G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E I R R C R L G E E V Q S E G W H H R R S L Q R
Helix box plot — Download: PNG | SVG L L T A L S L S Y G V T Y M V Q L R E L 1 I N L F T S F M L R A A A I L S R D R L 2 V L L W T Y N A G V C Y Q T V I Q A T R 3 H F R Y Y L L G L W G A P A L F V I P W V 4 F I L F N I L I T M L I P T R I I W W I A 5 L T L V P L L G V H E V V F A P V 6 V S V L F G Q F S S L F I E F G L K A 7

GPCRdb(A)
GPCRdb(B)
GIP receptor
TM1
1x25 1.29x29 F127
1x26 1.30x30 L128
1x29 1.33x33 R131
1x32 1.36x36 L134
1x33 1.37x37 E135
1x36 1.40x40 Q138
1x39 1.43x43 Y141
1x43 1.47x47 Y145
TM2
2x53 2.60x60 R183
2x57 2.64x64 I187
2x60 2.67x67 R190
TM3
3x36 3.40x40 V227
ECL2
45x52 45.52x52 E288
TM5
5x41 5.36x37 W296
TM7
7x30 7.35x34 R370
7x37 7.42x41 E377
7x38 7.43x42 I378