Structure information

GIP receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7FIY

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-28683-0

PUBLICATION DATE

March 2, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
tirzepatide Q30 N-term polar (hydrogen bond with backbone)
tirzepatide Q30 N-term Van der Waals
tirzepatide T31 N-term Van der Waals
tirzepatide A32 N-term Van der Waals
tirzepatide L35 N-term Van der Waals
tirzepatide L35 N-term hydrophobic
tirzepatide Y36 N-term hydrophobic
tirzepatide Y36 N-term Van der Waals
tirzepatide W39 N-term Van der Waals
tirzepatide W39 N-term aromatic (face-to-edge)
tirzepatide M67 N-term Van der Waals
tirzepatide M67 N-term hydrophobic
tirzepatide Y68 N-term Van der Waals
tirzepatide Y68 N-term hydrophobic
tirzepatide Y87 N-term Van der Waals
tirzepatide R113 N-term polar (charge-assisted hydrogen bond)
tirzepatide H115 N-term Van der Waals
tirzepatide N124 N-term Van der Waals
tirzepatide N124 N-term polar (hydrogen bond with backbone)
tirzepatide F127 1.29x29 TM1 hydrophobic
tirzepatide L128 1.30x30 TM1 Van der Waals
tirzepatide Q130 1.32x32 TM1 Van der Waals
tirzepatide L134 1.36x36 TM1 Van der Waals
tirzepatide L134 1.36x36 TM1 hydrophobic
tirzepatide L137 1.39x39 TM1 hydrophobic
tirzepatide Q138 1.40x40 TM1 Van der Waals
tirzepatide Y141 1.43x43 TM1 aromatic (edge-to-face)
tirzepatide Y141 1.43x43 TM1 Van der Waals
tirzepatide Y145 1.47x47 TM1 polar (hydrogen bond)
tirzepatide R183 2.60x60 TM2 polar (charge-assisted hydrogen bond)
tirzepatide R190 2.67x67 TM2 polar (charge-assisted hydrogen bond)
tirzepatide R196 ECL1 polar (charge-assisted hydrogen bond)
tirzepatide P197 ECL1 hydrophobic
tirzepatide P197 ECL1 Van der Waals
tirzepatide Y200 ECL1 Van der Waals
tirzepatide Y200 ECL1 hydrophobic
tirzepatide Q224 3.37x37 TM3 Van der Waals
tirzepatide V227 3.40x40 TM3 hydrophobic
tirzepatide V227 3.40x40 TM3 Van der Waals
tirzepatide E288 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
tirzepatide E288 45.52x52 ECL2 polar (hydrogen bond with backbone)
tirzepatide R289 ECL2 polar (charge-assisted hydrogen bond)
tirzepatide N290 ECL2 Van der Waals
tirzepatide N290 ECL2 polar (hydrogen bond)
tirzepatide W296 5.36x37 TM5 hydrophobic
tirzepatide W296 5.36x37 TM5 Van der Waals
tirzepatide R300 5.40x40 TM5 polar (charge-assisted hydrogen bond)
tirzepatide R370 7.35x34 TM7 polar (charge-assisted hydrogen bond)
tirzepatide L374 7.39x38 TM7 hydrophobic
tirzepatide L374 7.39x38 TM7 Van der Waals
tirzepatide I378 7.43x42 TM7 hydrophobic
tirzepatide I378 7.43x42 TM7 Van der Waals
tirzepatide S381 7.46x45 TM7 polar (hydrogen bond)

Ligands

tirzepatide

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Residue Diagrams

L L T A L S L S Y G V T Y M V Q L R E L 1 I N L F T S F M L R A A A I L S R D R L 2 V L L W T Y N A G V C Y Q T V I Q A T R 3 H F R Y Y L L G L W G A P A L F V I P W V 4 F I L F N I L I T M L I P T R I I W W I A 5 L T L V P L L G V H E V V F A P V 6 V S V L F G Q F S S L F I E F G L K A 7
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ICL1 R R L H ICL1ECL1 P R P G P Y L G D Q A L A L W N ECL1ICL2 V G G S E E G ICL2ECL2 N T Q C W E R N E V ECL2ICL3 Q M ICL3ECL3 T E E Q A R ECL3N-term M T T S P I L Q L L L R L S L C G L L L Q R A E T G S K G Q T A G E L Y Q R W E R Y R R E C Q E T L A A A E P P S G L A C N G S F D M Y V C W D Y A A P N A T A R A S C P W Y L P W H H H V A A G F V L R Q C G S D G Q W G L W R D H T Q C E N P E K N-termC-term Q L P E R A F R A L P S G S G P G E V P T S R G L S S G T L P G P G N E A S R E L E S Y C C-term N E A F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F C T R N Y I H I N L F T S F M L R A A A I L S R D R L L Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R R C R D Y R L R L A R S T L T L V P L L G V H E V V F A P V G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E I R R C R L G E E V Q S E G W H H R R S L Q R
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Residue Table


GPCRdb(A)
GPCRdb(B)
GIP receptor
TM1
1x25 1.29x29 F127
1x26 1.30x30 L128
1x28 1.32x32 Q130
1x32 1.36x36 L134
1x35 1.39x39 L137
1x36 1.40x40 Q138
1x39 1.43x43 Y141
1x43 1.47x47 Y145
TM2
2x53 2.60x60 R183
2x60 2.67x67 R190
TM3
3x33 3.37x37 Q224
3x36 3.40x40 V227
ECL2
45x52 45.52x52 E288
TM5
5x41 5.36x37 W296
5x44 5.40x40 R300
TM7
7x30 7.35x34 R370
7x34 7.39x38 L374
7x38 7.43x42 I378
7x41 7.46x45 S381