Structure information

BLT1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7K15

SPECIES

Homo sapiens

RESOLUTION

2.880

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Feb. 17, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide V67 2.53x53 TM2 hydrophobic
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide F74 2.60x60 TM2 polar (hydrogen bond with backbone)
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide H94 3.29x29 TM3 polar (hydrogen bond)
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide H94 3.29x29 TM3 aromatic (edge-to-face)
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide H94 3.29x29 TM3 polar (hydrogen bond)
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide C97 3.32x32 TM3 hydrophobic
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide R156 4.64x65 TM4 polar (charge-assisted hydrogen bond)
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide R156 4.64x65 TM4 polar (charge-assisted hydrogen bond)
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide R156 4.64x65 TM4 polar (charge-assisted hydrogen bond)
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide C168 45.50x50 ECL2 polar (hydrogen bond with backbone)
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide C168 45.50x50 ECL2 polar (hydrogen bond with backbone)
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide W234 6.48x48 TM6 aromatic (edge-to-face)
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide I271 7.39x38 TM7 hydrophobic
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide A274 7.42x41 TM7 hydrophobic
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide F275 7.43x42 TM7 aromatic (face-to-edge)

Ligands

N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide

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Residue Diagrams

S N G P L G V A L A V S L L I I A L L S 1 L N L A L A D L A V L L T A P F F L H F 2 A T I L L V S A Y M S V G C V Y H C L R 3 A R R V L A G I W V L S F L L A T P V 4 Y S A V V A L F P L L F G T V A E F I L H 5 V L I I L T F A A F W L P Y H V V N L A 6 V P N V S S S L F A L A I L V N R A L 7
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ICL1 M Q K R ICL1ECL1 T W S F ECL1ICL2 P F V S Q K L R ICL2ECL2 T V V P W K T N M S L C F P R Y P ECL2ICL3 R F R R ICL3ECL3 Q A A G L ECL3N-term M N T T S S A A P P S L N-termC-term G V G F V A K L L E G T G S E A S S T R R G G S L G Q T A R S G P A A L E P G P S E S L T A S S P L K L N E L N C-term G V E F I S L L A I I L L S V A L A V G L P G N S F V V W S I L K R S V T A L M V L N L A L A D L A V L L T A P F F L H F L A Q G G L A G C R L C H Y V C G V S M Y A S V L L I T A M S L D R S L A V A R T K A M A R R V L A G I W V L S F L L A T P V L A Y R S E G H R A F H L I F E A V T G F L L P F L A V V A S Y S D I G R R L Q A R S R R T G R L V V L I I L T F A A F W L P Y H V V N L A E A G R A L A G G L V G K R L S L A R N V L I A L A F L S S S V N P V L Y A C A G G G L L R S A
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Residue Table


GPCRdb(A)
GPCRdb(A)
BLT1 receptor
TM2
2x53 2.53x53 V67
2x60 2.60x60 F74
TM3
3x29 3.29x29 H94
3x32 3.32x32 C97
TM4
4x65 4.64x65 R156
ECL2
45x50 45.50x50 C168
TM6
6x48 6.48x48 W234
TM7
7x38 7.39x38 I271
7x41 7.42x41 A274
7x42 7.43x42 F275