Structure information

NTS1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7L0Q

SPECIES

Rattus norvegicus

RESOLUTION

4.300

PREFERRED CHAIN

C

REFERENCE

10.1038/S41594-020-00554-6

PUBLICATION DATE

Jan. 6, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
neurotensin L55 N-term polar (hydrogen bond with backbone)
neurotensin L55 N-term Van der Waals
neurotensin F128 ECL1 Van der Waals
neurotensin F128 ECL1 hydrophobic
neurotensin H133 ECL1 polar (hydrogen bond)
neurotensin Y146 3.29x29 TM3 polar (hydrogen bond)
neurotensin V224 ECL2 Van der Waals
neurotensin V224 ECL2 hydrophobic
neurotensin T226 45.51x51 ECL2 Van der Waals
neurotensin T231 5.32x33 TM5 Van der Waals
neurotensin R327 6.54x54 TM6 polar (charge-assisted hydrogen bond)
neurotensin R328 6.55x55 TM6 Van der Waals
neurotensin F331 6.58x58 TM6 Van der Waals
neurotensin F331 6.58x58 TM6 hydrophobic
neurotensin C332 6.59x59 TM6 Van der Waals
neurotensin I334 6.61x61 TM6 polar (hydrogen bond with backbone)
neurotensin I334 6.61x61 TM6 Van der Waals
neurotensin S335 ECL3 Van der Waals
neurotensin D336 ECL3 polar (charge-assisted hydrogen bond)
neurotensin W339 ECL3 Van der Waals
neurotensin W339 ECL3 hydrophobic
neurotensin F344 7.28x27 TM7 hydrophobic
neurotensin F344 7.28x27 TM7 Van der Waals
neurotensin Y347 7.31x30 TM7 polar (hydrogen bond)
neurotensin Y347 7.31x30 TM7 Van der Waals
neurotensin Y351 7.35x34 TM7 Van der Waals
neurotensin Y351 7.35x34 TM7 hydrophobic

Ligands

neurotensin

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Residue Diagrams

S N G V T G V V F L A L Y I A T V L V K 1 G S L A L S D L L I L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A I P M 4 N L I S I V L M P F L F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I A S S V Y F L A N T L M Y F Y 7
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ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G L Q N R S G D G T H P G G L V C T P I V D ECL2ICL3 R V C T V G T H N G L E H S T F N M T I E ICL3ECL3 S D E Q W ECL3N-term M H L N S S V P Q G T P G E P D A Q P F S G P Q S E M E A T F L A L S L S N G S G N T S E S D T A G P N S D L D V N T D N-termC-term P G W R H R R K K R P T F S R K P N S M S S N H A F S T S A T R E T L Y C-term I Y S K V L V T A I Y L A L F V V G T V G N S V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L I L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A I P M L F T M T A T V K V V I Q V N T F M S F L F P M L V I S I L N T V I A N K L T V M V H Q A A E Q G P G R V Q A L R H G V L V L R A V V I A F V V C W L P Y H V R R L M F C Y I T T F L F D F Y H Y F Y M L T N A L F Y V S S A I N P I L Y N L V S A N F L S L C F R Q V T L A C
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Residue Table


GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM3
3x29 3.29x29 Y146
ECL2
45x51 45.51x51 T226
TM5
5x33 5.32x33 T231
TM6
6x54 6.54x54 R327
6x55 6.55x55 R328
6x58 6.58x58 F331
6x59 6.59x59 C332
6x61 6.61x61 I334
TM7
7x27 7.28x27 F344
7x30 7.31x30 Y347
7x34 7.35x34 Y351