Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7LCI

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

10.1016/J.STR.2021.04.008

PUBLICATION DATE

Jan. 20, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
danuglipron L32 N-term hydrophobic
danuglipron W33 N-term hydrophobic
danuglipron V36 N-term hydrophobic
danuglipron Q37 N-term polar (hydrogen bond)
danuglipron L141 1.36x36 TM1 Van der Waals
danuglipron K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
danuglipron L201 2.71x71 TM2 hydrophobic
danuglipron L201 2.71x71 TM2 Van der Waals
danuglipron W203 ECL1 Van der Waals
danuglipron W203 ECL1 hydrophobic
danuglipron S206 ECL1 Van der Waals
danuglipron T207 ECL1 Van der Waals
danuglipron L217 ECL1 polar (hydrogen bond with backbone)
danuglipron L217 ECL1 Van der Waals
danuglipron Q221 ECL1 Van der Waals
danuglipron F230 3.33x33 TM3 Van der Waals
danuglipron F230 3.33x33 TM3 aromatic (edge-to-face)
danuglipron M233 3.36x36 TM3 Van der Waals
danuglipron C296 45.50x50 ECL2 Van der Waals
danuglipron T298 45.52x52 ECL2 Van der Waals
danuglipron R380 7.35x34 TM7 polar (charge-assisted hydrogen bond)
danuglipron F381 7.36x35 TM7 hydrophobic
danuglipron F381 7.36x35 TM7 Van der Waals
danuglipron L384 7.39x38 TM7 Van der Waals
danuglipron L384 7.39x38 TM7 hydrophobic

Ligands

danuglipron

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
TM2
2x60 2.67x67 K197
2x64 2.71x71 L201
TM3
3x29 3.33x33 F230
3x32 3.36x36 M233
ECL2
45x50 45.50x50 C296
45x52 45.52x52 T298
TM7
7x30 7.35x34 R380
7x31 7.36x35 F381
7x34 7.39x38 L384