PDB
7LLL
Resolution
3.7 Å
Released
Jan. 12, 2022
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
Exendin-4
Function
Agonist
Reference
10.1038/S41467-021-27760-0

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Ligand Amino Acid Generic Number Segment Interaction Type
Exendin-4 V30 N-term polar (hydrogen bond with backbone)
Exendin-4 V30 N-term Van der Waals
Exendin-4 L32 N-term Van der Waals
Exendin-4 E68 N-term Van der Waals
Exendin-4 L89 N-term Van der Waals
Exendin-4 L89 N-term hydrophobic
Exendin-4 L144 1.39x39 TM1 Van der Waals
Exendin-4 Y148 1.43x43 TM1 Van der Waals
Exendin-4 Y148 1.43x43 TM1 aromatic (face-to-edge)
Exendin-4 Y152 1.47x47 TM1 Van der Waals
Exendin-4 Y152 1.47x47 TM1 polar (hydrogen bond)
Exendin-4 R190 2.60x60 TM2 Van der Waals
Exendin-4 K197 2.67x67 TM2 Van der Waals
Exendin-4 Y205 2.75x75 TM2 polar (hydrogen bond)
Exendin-4 Y205 2.75x75 TM2 Van der Waals
Exendin-4 W214 ECL1 Van der Waals
Exendin-4 W214 ECL1 hydrophobic
Exendin-4 M233 3.36x36 TM3 Van der Waals
Exendin-4 V237 3.40x40 TM3 Van der Waals
Exendin-4 T298 45.52x52 ECL2 polar (hydrogen bond)
Exendin-4 T298 45.52x52 ECL2 polar (hydrogen bond with backbone)
Exendin-4 T298 45.52x52 ECL2 Van der Waals
Exendin-4 W306 5.36x37 TM5 hydrophobic
Exendin-4 W306 5.36x37 TM5 Van der Waals

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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x35 1.39x39 L144
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x53 2.60x60 R190
2x60 2.67x67 K197
2x68 2.75x75 Y205
TM3
3x32 3.36x36 M233
3x36 3.40x40 V237
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306