Structure information

MC4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7PIU

SPECIES

Homo sapiens

RESOLUTION

2.580

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-021-00569-8

PUBLICATION DATE

Nov. 17, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
setmelanotide F51 1.39x39 TM1 aromatic (face-to-face)
setmelanotide N97 2.57x57 TM2 polar (hydrogen bond)
setmelanotide N97 2.57x57 TM2 polar (hydrogen bond with backbone)
setmelanotide E100 2.60x60 TM2 polar (charge-assisted hydrogen bond)
setmelanotide T101 2.61x61 TM2 polar (hydrogen bond)
setmelanotide I104 2.64x64 TM2 Van der Waals
setmelanotide D122 3.25x25 TM3 polar (charge-assisted hydrogen bond)
setmelanotide N123 3.26x26 TM3 polar (hydrogen bond)
setmelanotide D126 3.29x29 TM3 polar (charge-assisted hydrogen bond)
setmelanotide I129 3.32x32 TM3 hydrophobic
setmelanotide I129 3.32x32 TM3 Van der Waals
setmelanotide C130 3.33x33 TM3 Van der Waals
setmelanotide C130 3.33x33 TM3 hydrophobic
setmelanotide I185 4.61x61 TM4 Van der Waals
setmelanotide I185 4.61x61 TM4 hydrophobic
setmelanotide S188 4.64x64 TM4 polar (hydrogen bond)
setmelanotide S188 4.64x64 TM4 polar (hydrogen bond with backbone)
setmelanotide S188 4.64x64 TM4 Van der Waals
setmelanotide I194 5.40x40 TM5 Van der Waals
setmelanotide I194 5.40x40 TM5 hydrophobic
setmelanotide L197 5.43x43 TM5 Van der Waals
setmelanotide L197 5.43x43 TM5 hydrophobic
setmelanotide F261 6.51x51 TM6 hydrophobic
setmelanotide F261 6.51x51 TM6 Van der Waals
setmelanotide H264 6.54x54 TM6 polar (hydrogen bond)
setmelanotide H264 6.54x54 TM6 Van der Waals
setmelanotide L265 6.55x55 TM6 hydrophobic
setmelanotide Y268 6.58x58 TM6 hydrophobic
setmelanotide Y268 6.58x58 TM6 Van der Waals
setmelanotide F284 7.35x34 TM7 hydrophobic
setmelanotide F284 7.35x34 TM7 Van der Waals
setmelanotide N285 7.36x35 TM7 Van der Waals
setmelanotide L288 7.39x38 TM7 Van der Waals
setmelanotide L288 7.39x38 TM7 hydrophobic

Ligands

setmelanotide

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Residue Diagrams

I N E L L S I V G L T V F V E P S 1 C S L A V A D M L V S V S N G S E T I V 2 S L L S C I S A L L S S C I V S D I V N 3 V G I I I S C I W A A C T V S G I L F I 4 Y L S A M L A L M T F F M T I L C I I V 5 T I L I G V F V V C W A P F F L H L I F 6 L P D I I S N C M I L I L Y L N F H 7
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ICL1 K N L H ICL1ECL1 N S T D T D A ECL1ICL2 A L Q Y H N I M ICL2ECL2 D ECL2ICL3 P G T G A I R ICL3ECL3 P Q N P Y C V C F M S ECL3N-term M V N S T H R G M H T S L H L W N R S S Y R L H S N A S E S L G K G Y S D G G C Y E Q L F V N-termC-term P L G G L C D L S S R Y C-term S P E V F V T L G V I S L L E N I L V I V A I A K N S P M Y F F I C S L A V A D M L V S V S N G S E T I V I T L L Q S F T V N I D N V I D S V I C S S L L A S I C S L L S I A V D R Y F T I F Y T V K R V G I I I S C I W A A C T V S G I L F I I Y S S S A V I I C L I T M F F T M L A L M A S L Y V H M F L M A R L H I K R I A V L Q G A N M K G A I T L T I L I G V F V V C W A P F F L H L I F Y I S C H F N L Y L I L I M C N S I I D P L I Y A L R S Q E F K E Y L R K T I I C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC4 receptor
TM1
1x39 1.39x39 F51
TM2
2x57 2.57x57 N97
2x60 2.60x60 E100
2x61 2.61x61 T101
2x64 2.64x64 I104
TM3
3x25 3.25x25 D122
3x26 3.26x26 N123
3x29 3.29x29 D126
3x32 3.32x32 I129
3x33 3.33x33 C130
TM4
4x61 4.61x61 I185
4x64 4.64x64 S188
TM5
5x40 5.40x40 I194
5x43 5.43x43 L197
TM6
6x51 6.51x51 F261
6x54 6.54x54 H264
6x55 6.55x55 L265
6x58 6.58x58 Y268
TM7
7x34 7.35x34 F284
7x35 7.36x35 N285
7x38 7.39x38 L288