Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7S15

SPECIES

Homo sapiens

RESOLUTION

3.800

PREFERRED CHAIN

R

REFERENCE

10.1021/acs.jmedchem.1c01856

PUBLICATION DATE

June 8, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL5191519 L32 N-term hydrophobic
CHEMBL5191519 W33 N-term aromatic (edge-to-face)
CHEMBL5191519 L141 1.36x36 TM1 hydrophobic
CHEMBL5191519 K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
CHEMBL5191519 L201 2.71x71 TM2 hydrophobic
CHEMBL5191519 L201 2.71x71 TM2 Van der Waals
CHEMBL5191519 W203 ECL1 Van der Waals
CHEMBL5191519 W203 ECL1 hydrophobic
CHEMBL5191519 L217 ECL1 hydrophobic
CHEMBL5191519 L217 ECL1 Van der Waals
CHEMBL5191519 Q221 ECL1 Van der Waals
CHEMBL5191519 Q221 ECL1 polar (hydrogen bond)
CHEMBL5191519 F230 3.33x33 TM3 aromatic (edge-to-face)
CHEMBL5191519 F230 3.33x33 TM3 Van der Waals
CHEMBL5191519 M233 3.36x36 TM3 Van der Waals
CHEMBL5191519 R380 7.35x34 TM7 polar (charge-assisted hydrogen bond)
CHEMBL5191519 F381 7.36x35 TM7 Van der Waals
CHEMBL5191519 F381 7.36x35 TM7 hydrophobic
CHEMBL5191519 L384 7.39x38 TM7 hydrophobic
CHEMBL5191519 L384 7.39x38 TM7 Van der Waals
CHEMBL5191519 F385 7.40x39 TM7 Van der Waals
CHEMBL5191519 F385 7.40x39 TM7 hydrophobic

Ligands

CHEMBL5191519

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
TM2
2x60 2.67x67 K197
2x64 2.71x71 L201
TM3
3x29 3.33x33 F230
3x32 3.36x36 M233
TM7
7x30 7.35x34 R380
7x31 7.36x35 F381
7x34 7.39x38 L384
7x35 7.40x39 F385