Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7S1M

SPECIES

Homo sapiens

RESOLUTION

2.410

PREFERRED CHAIN

R

REFERENCE

10.1038/S41589-021-00945-W

PUBLICATION DATE

Jan. 5, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
exendin-4 L32 N-term polar (hydrogen bond with backbone)
exendin-4 L32 N-term Van der Waals
exendin-4 W39 N-term Van der Waals
exendin-4 W39 N-term hydrophobic
exendin-4 E68 N-term Van der Waals
exendin-4 Y69 N-term hydrophobic
exendin-4 Y69 N-term Van der Waals
exendin-4 Y88 N-term Van der Waals
exendin-4 L89 N-term hydrophobic
exendin-4 L89 N-term Van der Waals
exendin-4 P90 N-term hydrophobic
exendin-4 P90 N-term Van der Waals
exendin-4 W91 N-term Van der Waals
exendin-4 W91 N-term hydrophobic
exendin-4 E138 1.33x33 TM1 polar (charge-assisted hydrogen bond)
exendin-4 L141 1.36x36 TM1 Van der Waals
exendin-4 L141 1.36x36 TM1 hydrophobic
exendin-4 L144 1.39x39 TM1 hydrophobic
exendin-4 L144 1.39x39 TM1 Van der Waals
exendin-4 Y148 1.43x43 TM1 aromatic (edge-to-face)
exendin-4 Y148 1.43x43 TM1 Van der Waals
exendin-4 Y152 1.47x47 TM1 polar (hydrogen bond)
exendin-4 Y152 1.47x47 TM1 Van der Waals
exendin-4 R190 2.60x60 TM2 Van der Waals
exendin-4 K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
exendin-4 L201 2.71x71 TM2 Van der Waals
exendin-4 L201 2.71x71 TM2 hydrophobic
exendin-4 Y205 2.75x75 TM2 Van der Waals
exendin-4 Y205 2.75x75 TM2 polar (hydrogen bond)
exendin-4 W214 ECL1 hydrophobic
exendin-4 W214 ECL1 Van der Waals
exendin-4 F230 3.33x33 TM3 Van der Waals
exendin-4 M233 3.36x36 TM3 Van der Waals
exendin-4 Q234 3.37x37 TM3 polar (hydrogen bond)
exendin-4 V237 3.40x40 TM3 Van der Waals
exendin-4 V237 3.40x40 TM3 hydrophobic
exendin-4 Y241 3.44x44 TM3 hydrophobic
exendin-4 T298 45.52x52 ECL2 Van der Waals
exendin-4 T298 45.52x52 ECL2 polar (hydrogen bond)
exendin-4 R299 ECL2 polar (charge-assisted hydrogen bond)
exendin-4 N300 ECL2 polar (hydrogen bond with backbone)
exendin-4 N300 ECL2 Van der Waals
exendin-4 W306 5.36x37 TM5 aromatic (edge-to-face)
exendin-4 W306 5.36x37 TM5 Van der Waals
exendin-4 I313 5.43x43 TM5 Van der Waals
exendin-4 D372 ECL3 polar (charge-assisted hydrogen bond)
exendin-4 R380 7.35x34 TM7 polar (charge-assisted hydrogen bond)
exendin-4 L384 7.39x38 TM7 hydrophobic
exendin-4 L384 7.39x38 TM7 Van der Waals
exendin-4 E387 7.42x41 TM7 polar (charge-assisted hydrogen bond)
exendin-4 L388 7.43x42 TM7 hydrophobic
exendin-4 L388 7.43x42 TM7 Van der Waals

Ligands

exendin-4

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x29 1.33x33 E138
1x32 1.36x36 L141
1x35 1.39x39 L144
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x53 2.60x60 R190
2x60 2.67x67 K197
2x64 2.71x71 L201
2x68 2.75x75 Y205
TM3
3x29 3.33x33 F230
3x32 3.36x36 M233
3x33 3.37x37 Q234
3x36 3.40x40 V237
3x40 3.44x44 Y241
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
5x47 5.43x43 I313
TM7
7x30 7.35x34 R380
7x34 7.39x38 L384
7x37 7.42x41 E387
7x38 7.43x42 L388