PDB
7SCG
Resolution
3.0 Å
Released
April 20, 2022
Receptor
μ
Class
A
Species
Mus musculus
Ligand
Function
FH210
Agonist
Reference
10.1002/ANIE.202200269

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Ligand Amino Acid Generic Number Segment Interaction Type
FH210 T120 2.56x56 TM2 Van der Waals
FH210 Q124 2.60x60 TM2 hydrophobic
FH210 N127 2.63x63 TM2 Van der Waals
FH210 W133 23.50x50 ECL1 Van der Waals
FH210 V143 3.28x28 TM3 hydrophobic
FH210 D147 3.32x32 TM3 polar (charge-charge)
FH210 D147 3.32x32 TM3 polar (hydrogen bond)
FH210 Y148 3.33x33 TM3 aromatic (pi-cation)
FH210 M151 3.36x36 TM3 hydrophobic
FH210 C217 45.50x50 ECL2 hydrophobic
FH210 V236 5.42x43 TM5 hydrophobic
FH210 I296 6.51x51 TM6 hydrophobic
FH210 V300 6.55x55 TM6 hydrophobic
FH210 Y326 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x56 2.56x56 T120
2x60 2.60x60 Q124
2x63 2.63x63 N127
ECL1
23x50 23.50x50 W133
TM3
3x28 3.28x28 V143
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x36 3.36x36 M151
ECL2
45x50 45.50x50 C217
TM5
5x43 5.42x43 V236
TM6
6x51 6.51x51 I296
6x55 6.55x55 V300
TM7
7x42 7.43x42 Y326