PDB
7SK4
Resolution
3.3 Å
Released
July 27, 2022
Receptor
ACKR3
Class
A
Species
Homo sapiens
Ligand
Function
CXCL12_LRHQ
Agonist
Reference
10.1126/SCIADV.ABN8063

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
CXCL12_LRHQ I27 N-term hydrophobic
CXCL12_LRHQ V28 N-term polar (hydrogen bond with backbone)
CXCL12_LRHQ V29 N-term hydrophobic
CXCL12_LRHQ D30 N-term polar (charge-charge)
CXCL12_LRHQ D30 N-term polar (hydrogen bond with backbone)
CXCL12_LRHQ T31 N-term Van der Waals
CXCL12_LRHQ V32 N-term polar (hydrogen bond with backbone)
CXCL12_LRHQ M33 N-term Van der Waals
CXCL12_LRHQ C34 N-term polar (hydrogen bond with backbone)
CXCL12_LRHQ N36 N-term Van der Waals
CXCL12_LRHQ W100 2.60x60 TM2 hydrophobic
CXCL12_LRHQ S103 2.63x63 TM2 polar (hydrogen bond)
CXCL12_LRHQ C117 3.25x25 TM3 hydrophobic
CXCL12_LRHQ H121 3.29x29 TM3 hydrophobic
CXCL12_LRHQ F124 3.32x32 TM3 Van der Waals
CXCL12_LRHQ L128 3.36x36 TM3 hydrophobic
CXCL12_LRHQ F129 3.37x37 TM3 hydrophobic
CXCL12_LRHQ D179 4.60x61 TM4 polar (hydrogen bond)
CXCL12_LRHQ D179 4.60x61 TM4 polar (charge-charge)
CXCL12_LRHQ L183 4.64x65 TM4 hydrophobic
CXCL12_LRHQ N191 ECL2 Van der Waals
CXCL12_LRHQ Y195 ECL2 Van der Waals
CXCL12_LRHQ C196 45.50x50 ECL2 Van der Waals
CXCL12_LRHQ R197 45.51x51 ECL2 aromatic (pi-cation)
CXCL12_LRHQ Y200 ECL2 Van der Waals
CXCL12_LRHQ I205 5.31x32 TM5 Van der Waals
CXCL12_LRHQ K206 5.32x33 TM5 Van der Waals
CXCL12_LRHQ L209 5.35x36 TM5 Van der Waals
CXCL12_LRHQ M212 5.38x39 TM5 Van der Waals
CXCL12_LRHQ E213 5.39x40 TM5 polar (charge-charge)
CXCL12_LRHQ E213 5.39x40 TM5 polar (hydrogen bond)
CXCL12_LRHQ S216 5.42x43 TM5 polar (hydrogen bond)
CXCL12_LRHQ Y268 6.51x51 TM6 Van der Waals
CXCL12_LRHQ D275 6.58x58 TM6 polar (hydrogen bond)
CXCL12_LRHQ D275 6.58x58 TM6 polar (charge-charge)
CXCL12_LRHQ I279 6.62x62 TM6 hydrophobic
CXCL12_LRHQ L280 6.63x63 TM6 hydrophobic
CXCL12_LRHQ L280 6.63x63 TM6 polar (hydrogen bond with backbone)
CXCL12_LRHQ H281 6.64x64 TM6 polar (hydrogen bond)
CXCL12_LRHQ H281 6.64x64 TM6 hydrophobic
CXCL12_LRHQ Y282 ECL3 polar (hydrogen bond)
CXCL12_LRHQ F285 ECL3 hydrophobic
CXCL12_LRHQ E290 7.28x27 TM7 polar (charge-charge)
CXCL12_LRHQ L293 7.31x30 TM7 Van der Waals
CXCL12_LRHQ F294 7.32x31 TM7 Van der Waals
CXCL12_LRHQ L297 7.35x34 TM7 Van der Waals
CXCL12_LRHQ Q301 7.39x38 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 K T T G ICL1ECL1 H N Q W P M ECL1ICL2 F T N T P S S R K K M ICL2ECL2 K T V T S A S N N E T Y C R S F Y P E H ECL2ICL3 S D ICL3ECL3 Y I P F ECL3N-term M D L H L F D Y S E P G N F S D I S W P C N S S D C I V V D T V M C P N M P N K N-termC-term Y S A K T G L T K L I D A S R V S E T E Y S A L E Q S T K C-term S V L L Y T L S F I Y I F I F V I G M I A N S V V V W V N I Q A Y D T H C Y I L N L A I A D L W V V L T I P V W V V S L V Q G E L T C K V T H L I F S I N L F G S I F F L T C M S V D R Y L S I T Y V R R V V C I L V W L L A F C V S L P D T Y Y L S I K E W L I G M E L V S V V L G F A V P F S I I A V F Y F L L A R A I S A S Q E K H S S R K I I F S Y V V V F L V C W L P Y H V A V L L D I F S I L H T C R L E H A L F T A L H V T Q C L S L V H C C V N P V L Y S F I N R N L M K K Y R Y E A F I F
Helix box plot — Download: PNG | SVG S N A I M G I V F I F I Y I F S L T Y L 1 L N L A I A D L W V V L T I P V W V V S 2 C T L F F I S G F L N I S F I L H T V K 3 R R V V C I L V W L L A F C V S L P D 4 Y F V A I I S F P V A F G L V V S V L E M 5 F S Y V V V F L V C W L P Y H V A V L L 6 V P N V C C H V L S L C Q T V H L A T 7

GPCRdb(A)
GPCRdb(A)
ACKR3
TM2
2x60 2.60x60 W100
2x63 2.63x63 S103
TM3
3x25 3.25x25 C117
3x29 3.29x29 H121
3x32 3.32x32 F124
3x36 3.36x36 L128
3x37 3.37x37 F129
TM4
4x61 4.60x61 D179
4x65 4.64x65 L183
ECL2
45x50 45.50x50 C196
45x51 45.51x51 R197
TM5
5x32 5.31x32 I205
5x33 5.32x33 K206
5x36 5.35x36 L209
5x39 5.38x39 M212
5x40 5.39x40 E213
5x43 5.42x43 S216
TM6
6x51 6.51x51 Y268
6x58 6.58x58 D275
6x62 6.62x62 I279
6x63 6.63x63 L280
6x64 6.64x64 H281
TM7
7x27 7.28x27 E290
7x30 7.31x30 L293
7x31 7.32x31 F294
7x34 7.35x34 L297
7x38 7.39x38 Q301