PDB
7SRQ
Resolution
2.7 Å
Released
Sept. 21, 2022
Receptor
5-HT2B
Class
A
Species
Homo sapiens
Ligand
Function
(+)-LSD
Agonist (partial)
Reference
10.1016/J.NEURON.2022.08.006

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Ligand Amino Acid Generic Number Segment Interaction Type
(+)-LSD W131 3.28x28 TM3 hydrophobic
(+)-LSD L132 3.29x29 TM3 hydrophobic
(+)-LSD D135 3.32x32 TM3 polar (hydrogen bond)
(+)-LSD D135 3.32x32 TM3 polar (charge-charge)
(+)-LSD V136 3.33x33 TM3 Van der Waals
(+)-LSD S139 3.36x36 TM3 Van der Waals
(+)-LSD T140 3.37x37 TM3 Van der Waals
(+)-LSD A225 5.46x461 TM5 Van der Waals
(+)-LSD W337 6.48x48 TM6 Van der Waals
(+)-LSD F340 6.51x51 TM6 hydrophobic
(+)-LSD F340 6.51x51 TM6 aromatic (edge-to-face)
(+)-LSD F341 6.52x52 TM6 aromatic (edge-to-face)
(+)-LSD N344 6.55x55 TM6 Van der Waals
(+)-LSD V366 7.39x38 TM7 hydrophobic

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ICL1 K K L Q ICL1ECL1 E A M W P L ECL1ICL2 P I Q A N Q Y N ICL2ECL2 I E T D V D N P N N I T C V L T K E R ECL2ICL3 P Q R L T W L T V S T V F Q R D E T P C S S P E K V A M L D G S R K D K A L P N S G D E T L M R R T S T I G K K S ICL3ECL3 D S C ECL3N-term M A L S Y R V S E L Q S T I P E H I L Q S T F V H V I S S N W S G L Q T E S I P E E M K Q I V E E Q G N N-termC-term T C N Y R A T K S V K T L R K R S S K I Y F R N P M A E N S K F F K K H G I R N G I N P A M Y Q S P M R L R S S T I Q S S S I I L L D T L L L T E N E G D K T E E Q V S Y V C-term K L H W A A L L I L M V I I P T I G G N T L V I L A V S L E Y A T N Y F L M S L A V A D L L V G L F V M P I A L L T I M F P L V L C P A W L F L D V L F S T A S I M H L C A I S V D R Y I A I K K S R A T A F I K I T V V W L I S I G I A I P V P I K G F G D F M L F G S L A A F F T P L A I M I V T Y F L T I H A L Q K K A Y L V K N K P V Q T I S N E Q R A S K V L G I V F F L F L L M W C P F F I T N I T L V L C N Q T T L Q M L L E I F V W I G Y V S S G V N P L V Y T L F N K T F G R F R D A Y I
Helix box plot — Download: PNG | SVG T N G G I T P I I V M L I L L A A W H L K 1 M S L A V A D L L V G F L V M P I A L L T 2 A C L H M I S A T S F L V D L F L W A P 3 A F I K I T V V W L I S I G I A I P V 4 Y T V I M I A L P T F F A A L S G F L M F 5 G I V F F L F L L M W C P F F I T N I T 6 L P N V G S S V Y G I W V F I E L L M 7

GPCRdb(A)
GPCRdb(A)
5-HT2B receptor
TM3
3x28 3.28x28 W131
3x29 3.29x29 L132
3x32 3.32x32 D135
3x33 3.33x33 V136
3x36 3.36x36 S139
3x37 3.37x37 T140
TM5
5x461 5.46x461 A225
TM6
6x48 6.48x48 W337
6x51 6.51x51 F340
6x52 6.52x52 F341
6x55 6.55x55 N344
TM7
7x38 7.39x38 V366