PDB
7T2G
Resolution
2.5 Å
Released
Dec. 7, 2022
Receptor
μ
Class
A
Species
Mus musculus
Ligand
Function
Mitragynine pseudoindoxyl
Agonist (partial)
Reference
10.1038/S41589-022-01208-Y

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Ligand Amino Acid Generic Number Segment Interaction Type
Mitragynine pseudoindoxyl Y75 1.39x39 TM1 hydrophobic
Mitragynine pseudoindoxyl Y75 1.39x39 TM1 aromatic (edge-to-face)
Mitragynine pseudoindoxyl L121 2.57x57 TM2 Van der Waals
Mitragynine pseudoindoxyl Q124 2.60x60 TM2 hydrophobic
Mitragynine pseudoindoxyl I144 3.29x29 TM3 hydrophobic
Mitragynine pseudoindoxyl D147 3.32x32 TM3 hydrophobic
Mitragynine pseudoindoxyl D147 3.32x32 TM3 polar (charge-charge)
Mitragynine pseudoindoxyl D147 3.32x32 TM3 polar (hydrogen bond)
Mitragynine pseudoindoxyl Y148 3.33x33 TM3 hydrophobic
Mitragynine pseudoindoxyl M151 3.36x36 TM3 hydrophobic
Mitragynine pseudoindoxyl V236 5.42x43 TM5 Van der Waals
Mitragynine pseudoindoxyl W293 6.48x48 TM6 Van der Waals
Mitragynine pseudoindoxyl I296 6.51x51 TM6 Van der Waals
Mitragynine pseudoindoxyl H297 6.52x52 TM6 Van der Waals
Mitragynine pseudoindoxyl V300 6.55x55 TM6 Van der Waals
Mitragynine pseudoindoxyl W318 7.35x34 TM7 Van der Waals
Mitragynine pseudoindoxyl H319 7.36x35 TM7 Van der Waals
Mitragynine pseudoindoxyl I322 7.39x38 TM7 hydrophobic
Mitragynine pseudoindoxyl G325 7.42x41 TM7 Van der Waals
Mitragynine pseudoindoxyl Y326 7.43x42 TM7 hydrophobic
Mitragynine pseudoindoxyl Y326 7.43x42 TM7 polar (hydrogen bond)

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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM1
1x39 1.39x39 Y75
TM2
2x57 2.57x57 L121
2x60 2.60x60 Q124
TM3
3x29 3.29x29 I144
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x36 3.36x36 M151
TM5
5x43 5.42x43 V236
TM6
6x48 6.48x48 W293
6x51 6.51x51 I296
6x52 6.52x52 H297
6x55 6.55x55 V300
TM7
7x34 7.35x34 W318
7x35 7.36x35 H319
7x38 7.39x38 I322
7x41 7.42x41 G325
7x42 7.43x42 Y326