Structure information

μ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7T2G

SPECIES

Mus musculus

RESOLUTION

2.500

PREFERRED CHAIN

R

REFERENCE

10.1038/S41589-022-01208-Y

PUBLICATION DATE

Dec. 7, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL58362 Y75 1.39x39 TM1 hydrophobic
CHEMBL58362 I144 3.29x29 TM3 hydrophobic
CHEMBL58362 D147 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL58362 Y148 3.33x33 TM3 hydrophobic
CHEMBL58362 Y148 3.33x33 TM3 Van der Waals
CHEMBL58362 M151 3.36x36 TM3 Van der Waals
CHEMBL58362 W293 6.48x48 TM6 Van der Waals
CHEMBL58362 W293 6.48x48 TM6 hydrophobic
CHEMBL58362 I296 6.51x51 TM6 Van der Waals
CHEMBL58362 I296 6.51x51 TM6 hydrophobic
CHEMBL58362 H297 6.52x52 TM6 Van der Waals
CHEMBL58362 V300 6.55x55 TM6 Van der Waals
CHEMBL58362 H319 7.36x35 TM7 Van der Waals
CHEMBL58362 I322 7.39x38 TM7 hydrophobic
CHEMBL58362 I322 7.39x38 TM7 Van der Waals
CHEMBL58362 Y326 7.43x42 TM7 polar (hydrogen bond)

Ligands

CHEMBL58362

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Residue Diagrams

F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7
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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
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Residue Table


GPCRdb(A)
GPCRdb(A)
μ receptor
TM1
1x39 1.39x39 Y75
TM3
3x29 3.29x29 I144
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x36 3.36x36 M151
TM6
6x48 6.48x48 W293
6x51 6.51x51 I296
6x52 6.52x52 H297
6x55 6.55x55 V300
TM7
7x35 7.36x35 H319
7x38 7.39x38 I322
7x42 7.43x42 Y326