Structure information

μ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7T2H

SPECIES

Mus musculus

RESOLUTION

3.200

PREFERRED CHAIN

D

REFERENCE

10.1038/S41589-022-01208-Y

PUBLICATION DATE

Dec. 7, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
LOFENTANIL W133 23.50x50 ECL1 aromatic (face-to-edge)
LOFENTANIL I144 3.29x29 TM3 hydrophobic
LOFENTANIL D147 3.32x32 TM3 polar (charge-assisted hydrogen bond)
LOFENTANIL Y148 3.33x33 TM3 hydrophobic
LOFENTANIL Y148 3.33x33 TM3 Van der Waals
LOFENTANIL M151 3.36x36 TM3 hydrophobic
LOFENTANIL M151 3.36x36 TM3 Van der Waals
LOFENTANIL V236 5.42x43 TM5 Van der Waals
LOFENTANIL W293 6.48x48 TM6 hydrophobic
LOFENTANIL W293 6.48x48 TM6 Van der Waals
LOFENTANIL I296 6.51x51 TM6 hydrophobic
LOFENTANIL H297 6.52x52 TM6 Van der Waals
LOFENTANIL W318 7.35x34 TM7 Van der Waals
LOFENTANIL I322 7.39x38 TM7 Van der Waals
LOFENTANIL I322 7.39x38 TM7 hydrophobic
LOFENTANIL G325 7.42x41 TM7 Van der Waals
LOFENTANIL Y326 7.43x42 TM7 Van der Waals
LOFENTANIL Y326 7.43x42 TM7 aromatic (face-to-face)

Ligands

LOFENTANIL

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Residue Diagrams

F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7
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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
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Residue Table


GPCRdb(A)
GPCRdb(A)
μ receptor
ECL1
23x50 23.50x50 W133
TM3
3x29 3.29x29 I144
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x36 3.36x36 M151
TM5
5x43 5.42x43 V236
TM6
6x48 6.48x48 W293
6x51 6.51x51 I296
6x52 6.52x52 H297
TM7
7x34 7.35x34 W318
7x38 7.39x38 I322
7x41 7.42x41 G325
7x42 7.43x42 Y326