Structure information

S1P1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7TD3

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-28417-2

PUBLICATION DATE

Feb. 9, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
sphingosine 1-phosphate Y29 N-term polar (hydrogen bond)
sphingosine 1-phosphate Y29 N-term Van der Waals
sphingosine 1-phosphate K34 N-term polar (charge-assisted hydrogen bond)
sphingosine 1-phosphate N101 2.60x60 TM2 polar (hydrogen bond)
sphingosine 1-phosphate S105 ECL1 Van der Waals
sphingosine 1-phosphate G106 23.47x47 ECL1 Van der Waals
sphingosine 1-phosphate G106 23.47x47 ECL1 polar (hydrogen bond with backbone)
sphingosine 1-phosphate T109 23.50x50 ECL1 polar (hydrogen bond)
sphingosine 1-phosphate T109 23.50x50 ECL1 Van der Waals
sphingosine 1-phosphate R120 3.28x28 TM3 polar (charge-assisted hydrogen bond)
sphingosine 1-phosphate E121 3.29x29 TM3 Van der Waals
sphingosine 1-phosphate M124 3.32x32 TM3 hydrophobic
sphingosine 1-phosphate M124 3.32x32 TM3 Van der Waals
sphingosine 1-phosphate F125 3.33x33 TM3 hydrophobic
sphingosine 1-phosphate F125 3.33x33 TM3 Van der Waals
sphingosine 1-phosphate L128 3.36x36 TM3 Van der Waals
sphingosine 1-phosphate L128 3.36x36 TM3 hydrophobic
sphingosine 1-phosphate S129 3.37x37 TM3 Van der Waals
sphingosine 1-phosphate L195 ECL2 hydrophobic
sphingosine 1-phosphate F210 5.47x47 TM5 hydrophobic
sphingosine 1-phosphate F210 5.47x47 TM5 Van der Waals
sphingosine 1-phosphate L297 7.39x38 TM7 hydrophobic
sphingosine 1-phosphate L297 7.39x38 TM7 Van der Waals

Ligands

sphingosine 1-phosphate

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Residue Diagrams

I N E L I I F C C I L I F V V S T L K I 1 G N L A L S D L L A G V A Y T A N L L L 2 A L L S F V S A S L A V F M S G E R L F 3 L F L L I S A C W V I S L I L G G L P I 4 Y L I V I S L L L L T F V T T C F L I Y 5 I I V L S V F I A C W A P L F I L L L L 6 I P N T G S N L V A L V L F Y E A R F 7
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ICL1 K K F H ICL1ECL1 G A T T Y K L ECL1ICL2 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
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Residue Table


GPCRdb(A)
GPCRdb(A)
S1P1 receptor
TM2
2x60 2.60x60 N101
ECL1
23x47 23.47x47 G106
23x50 23.50x50 T109
TM3
3x28 3.28x28 R120
3x29 3.29x29 E121
3x32 3.32x32 M124
3x33 3.33x33 F125
3x36 3.36x36 L128
3x37 3.37x37 S129
TM5
5x47 5.47x47 F210
TM7
7x38 7.39x38 L297