Structure information

M4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7TRQ

SPECIES

Homo sapiens

RESOLUTION

2.500

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

May 17, 2023

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Ligand Interaction Browser

Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
VU0467154 Y89 2.61x60 TM2 polar (hydrogen bond)
VU0467154 Y89 2.61x60 TM2 Van der Waals
VU0467154 Y92 2.64x63 TM2 Van der Waals
VU0467154 Y92 2.64x63 TM2 hydrophobic
VU0467154 I93 2.65x64 TM2 Van der Waals
VU0467154 I93 2.65x64 TM2 polar (hydrogen bond with backbone)
VU0467154 G96 2.68x67 TM2 Van der Waals
VU0467154 Q184 ECL2 polar (hydrogen bond)
VU0467154 Q184 ECL2 polar (hydrogen bond)
VU0467154 F186 45.51x51 ECL2 aromatic (face-to-face)
VU0467154 F186 45.51x51 ECL2 Van der Waals
VU0467154 L190 ECL2 Van der Waals
VU0467154 L190 ECL2 hydrophobic
VU0467154 D432 7.32x31 TM7 polar (charge-assisted hydrogen bond)
VU0467154 T433 7.33x32 TM7 Van der Waals
VU0467154 T433 7.33x32 TM7 polar (hydrogen bond)
VU0467154 W435 7.35x34 TM7 Van der Waals
VU0467154 W435 7.35x34 TM7 aromatic (face-to-face)
VU0467154 S436 7.36x35 TM7 Van der Waals
VU0467154 Y439 7.39x38 TM7 Van der Waals

Ligands

VU0467154

3D interaction viewer Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.


Residue Diagrams

I N G V V T V L S L S G T V T A I F V M 1 F S L A C A D L I I G F A S M N L Y T V Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G L M I A A A W V L S F V L W A P A I 4 Y L V T M I V V P L Y F A A I A T G F T V 5 F A I L L A F I L T W T P Y N V M V L V 6 A P N I T S N V Y C L W Y G I S W V T 7
Download: PNG | SVG
ICL1 R Q L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P A R R ICL2ECL2 K R T V P D N Q C F I Q F L S ECL2ICL3 G P K E K K A K T L A F L K S P L M K Q S V K K P P P G E A A R E E L R N G K L E E A P P P A L P P P P R P V A D K D T S N E S S S G S A T Q N T K E R P A T E L S T T E A T T P A M P A P P L Q P R A L N P A S R W S K I Q I V T K Q T G N E C V T A I E I V P A T P A G M R P A A N V A R K F A S I A R N Q V R K K ICL3ECL3 Q S C I ECL3N-term M A N F T P V N G S S G N Q S V R L V T S S S H N N-termC-term Y R N I G T A R C-term R Y E T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V H K H R P E R Q M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F R H Q F K K T L L L C
Download: PNG | SVG

Residue Table


GPCRdb(A)
GPCRdb(A)
M4 receptor
TM2
2x60 2.61x60 Y89
2x63 2.64x63 Y92
2x64 2.65x64 I93
2x67 2.68x67 G96
ECL2
45x51 45.51x51 F186
TM7
7x31 7.32x31 D432
7x32 7.33x32 T433
7x34 7.35x34 W435
7x35 7.36x35 S436
7x38 7.39x38 Y439