Structure information

M4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7TRS

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

May 17, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
acetylcholine Y113 3.33x33 TM3 hydrophobic
acetylcholine W164 4.57x57 TM4 Van der Waals
acetylcholine W164 4.57x57 TM4 polar (hydrogen bond)
acetylcholine A203 5.46x461 TM5 Van der Waals
acetylcholine W413 6.48x48 TM6 hydrophobic
acetylcholine W413 6.48x48 TM6 Van der Waals
acetylcholine Y416 6.51x51 TM6 hydrophobic
acetylcholine Y416 6.51x51 TM6 Van der Waals
acetylcholine Y439 7.39x38 TM7 hydrophobic
acetylcholine Y439 7.39x38 TM7 Van der Waals
acetylcholine C442 7.42x41 TM7 hydrophobic
acetylcholine C442 7.42x41 TM7 Van der Waals
acetylcholine Y443 7.43x42 TM7 hydrophobic
acetylcholine Y443 7.43x42 TM7 Van der Waals

Ligands

acetylcholine

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Residue Diagrams

I N G V V T V L S L S G T V T A I F V M 1 F S L A C A D L I I G F A S M N L Y T V Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G L M I A A A W V L S F V L W A P A I 4 Y L V T M I V V P L Y F A A I A T G F T V 5 F A I L L A F I L T W T P Y N V M V L V 6 A P N I T S N V Y C L W Y G I S W V T 7
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ICL1 R Q L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P A R R ICL2ECL2 K R T V P D N Q C F I Q F L S ECL2ICL3 G P K E K K A K T L A F L K S P L M K Q S V K K P P P G E A A R E E L R N G K L E E A P P P A L P P P P R P V A D K D T S N E S S S G S A T Q N T K E R P A T E L S T T E A T T P A M P A P P L Q P R A L N P A S R W S K I Q I V T K Q T G N E C V T A I E I V P A T P A G M R P A A N V A R K F A S I A R N Q V R K K ICL3ECL3 Q S C I ECL3N-term M A N F T P V N G S S G N Q S V R L V T S S S H N N-termC-term Y R N I G T A R C-term R Y E T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V H K H R P E R Q M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F R H Q F K K T L L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
M4 receptor
TM3
3x33 3.33x33 Y113
TM4
4x57 4.57x57 W164
TM5
5x461 5.46x461 A203
TM6
6x48 6.48x48 W413
6x51 6.51x51 Y416
TM7
7x38 7.39x38 Y439
7x41 7.42x41 C442
7x42 7.43x42 Y443