Structure information

CRF2 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7TS0

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

P

REFERENCE

10.1038/S41467-022-33851-3

PUBLICATION DATE

Nov. 9, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Urocortin N69 N-term Van der Waals
Urocortin N69 N-term polar (hydrogen bond)
Urocortin V71 N-term hydrophobic
Urocortin V71 N-term Van der Waals
Urocortin Y73 N-term Van der Waals
Urocortin Y73 N-term polar (hydrogen bond)
Urocortin L102 N-term hydrophobic
Urocortin L102 N-term Van der Waals
Urocortin D104 1.27x27 TM1 Van der Waals
Urocortin D110 1.33x33 TM1 Van der Waals
Urocortin Y113 1.36x36 TM1 hydrophobic
Urocortin Y113 1.36x36 TM1 Van der Waals
Urocortin W166 2.64x64 TM2 Van der Waals
Urocortin W166 2.64x64 TM2 polar (hydrogen bond)
Urocortin L169 2.67x67 TM2 hydrophobic
Urocortin Q170 2.68x68 TM2 Van der Waals
Urocortin D173 ECL1 Van der Waals
Urocortin H174 ECL1 Van der Waals
Urocortin H177 ECL1 Van der Waals
Urocortin F191 3.36x36 TM3 hydrophobic
Urocortin F191 3.36x36 TM3 Van der Waals
Urocortin N192 3.37x37 TM3 Van der Waals
Urocortin F199 3.44x44 TM3 Van der Waals
Urocortin F199 3.44x44 TM3 hydrophobic
Urocortin F256 45.52x52 ECL2 polar (hydrogen bond with backbone)
Urocortin F256 45.52x52 ECL2 Van der Waals
Urocortin K258 ECL2 polar (charge-assisted hydrogen bond)
Urocortin Y268 5.39x39 TM5 Van der Waals
Urocortin Q269 5.40x40 TM5 Van der Waals
Urocortin Q269 5.40x40 TM5 polar (hydrogen bond)
Urocortin Y323 6.53x53 TM6 Van der Waals
Urocortin Y323 6.53x53 TM6 polar (hydrogen bond with backbone)
Urocortin F326 ECL3 polar (hydrogen bond with backbone)
Urocortin F326 ECL3 Van der Waals
Urocortin F327 ECL3 polar (hydrogen bond with backbone)
Urocortin F327 ECL3 Van der Waals
Urocortin V328 ECL3 Van der Waals
Urocortin N329 ECL3 Van der Waals
Urocortin F340 7.38x37 TM7 Van der Waals
Urocortin F340 7.38x37 TM7 hydrophobic
Urocortin I341 7.39x38 TM7 Van der Waals
Urocortin I341 7.39x38 TM7 hydrophobic
Urocortin N344 7.42x41 TM7 polar (hydrogen bond)
Urocortin N344 7.42x41 TM7 Van der Waals
Urocortin S345 7.43x42 TM7 Van der Waals
Urocortin Q348 7.46x45 TM7 Van der Waals

Ligands

Urocortin

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Residue Diagrams

V L A A V S V C H G L Y N V V L A I R Y 1 W N L I T T F I L R N V M W F L L Q L V 2 V F M W F F N T V V F Y N F I T T I C R 3 R K C L F L F G I W C I P F P I I V A W A 4 L F V F N I L L V L I I P G Q Y I Y D V 5 L V L L P L L G I T Y M L F F V 6 V S V F F G Q F S Q L F S N F Y I F M 7
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ICL1 R S I R ICL1ECL1 D H E V H E S N ECL1ICL2 T Y S T E R L ICL2ECL2 N E Q C W F G K E P G D L ECL2ICL3 S T T ICL3ECL3 N P G E D ECL3N-term M D A A L L H S L L E A N C S L A L A E E L L L D G W G P P L D P E G P Y S Y C N T T L D Q I G T C W P R S A A G A L V E R P C P E Y F N G V K Y N T T R N A Y R E C L E N G T W A S K I N Y S Q C E N-termC-term R A M S I P T S P T R I S F H S I K Q T A A V C-term P I L D D K Q R K Y D L H Y R I A L V V N Y L G H C V S V A A L V A A F L L F L A L C L R N V I H W N L I T T F I L R N V M W F L L Q L V E V W C R C I T T I F N Y F V V T N F F W M F V E G C Y L H T A I V M R K C L F L F I G W C I P F P I I V A W A I G K L Y Y E V D Y I Y Q G P I I L V L L I N F V F L F N I V R I L M T K L R A S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V D L S Q I M F I Y F N S F L Q S F Q G F F V S V F Y C F F N G E V R K W Q D R V P V R S A R W H R H H S L M A
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Residue Table


GPCRdb(A)
GPCRdb(B)
CRF2 receptor
TM1
1x23 1.27x27 D104
1x29 1.33x33 D110
1x32 1.36x36 Y113
TM2
2x57 2.64x64 W166
2x60 2.67x67 L169
2x61 2.68x68 Q170
TM3
3x32 3.36x36 F191
3x33 3.37x37 N192
3x40 3.44x44 F199
ECL2
45x52 45.52x52 F256
TM5
5x43 5.39x39 Y268
5x44 5.40x40 Q269
TM6
6x48 6.53x53 Y323
TM7
7x33 7.38x37 F340
7x34 7.39x38 I341
7x37 7.42x41 N344
7x38 7.43x42 S345
7x41 7.46x45 Q348