PDB
7TUZ
Resolution
3.1 Å
Released
April 13, 2022
Receptor
GPR183
Class
A
Species
Homo sapiens
Ligand
Function
7α,25-dihydroxycholesterol
Agonist
Reference
10.1016/J.STR.2022.04.006

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
7α,25-dihydroxycholesterol R87 2.60x60 TM2 Van der Waals
7α,25-dihydroxycholesterol Y112 3.33x33 TM3 hydrophobic
7α,25-dihydroxycholesterol Y112 3.33x33 TM3 polar (hydrogen bond)
7α,25-dihydroxycholesterol Y116 3.37x37 TM3 Van der Waals
7α,25-dihydroxycholesterol Q162 4.56x56 TM4 hydrophobic
7α,25-dihydroxycholesterol M182 45.51x51 ECL2 hydrophobic
7α,25-dihydroxycholesterol Y184 ECL2 hydrophobic
7α,25-dihydroxycholesterol L197 5.39x40 TM5 hydrophobic
7α,25-dihydroxycholesterol A200 5.42x43 TM5 hydrophobic
7α,25-dihydroxycholesterol C201 5.43x44 TM5 Van der Waals
7α,25-dihydroxycholesterol Y260 6.51x51 TM6 Van der Waals
7α,25-dihydroxycholesterol L290 7.35x34 TM7 hydrophobic
7α,25-dihydroxycholesterol V294 7.39x38 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 R K K I ICL1ECL1 F D W R I ECL1ICL2 P L R Y N K I K ICL2ECL2 M S K Q E A E R I T C M E Y P N F E E T K ECL2ICL3 P L T E K S ICL3ECL3 S N F L E C ECL3N-term M D I Q M A N N F T P P S A T P Q G N D C D L Y A N-termC-term Q V S V S I S S A V K S A P E E N S R E M T E T Q M M I H S K S S N G K C-term H H S T A R I V M P L H Y S L V F I I G L V G N L L A L V V I V Q N N S T T L Y S T N L V I S D I L F T T A L P T R I A Y Y A M G G D A L C R I T A L V F Y I N T Y A G V N F M T C L S I D R F I A V V H R I E H A K G V C I F V W I L V F A Q T L P L L I N P S L P W I L L G A C F I G Y V L P L I I I L I C Y S Q I C C K L F R T A K Q N G V N K K A L N T I I L I I V V F V L C F T P Y H V A I I Q H M I K K L R F S Q R H S F Q I S L H F T V C L M N F N C C M D P F I Y F F A C K G V M R Y K R K M L K R
Helix box plot — Download: PNG | SVG L N G V L G I I F V L S Y H L P M V I R 1 T N L V I S D I L F T T A L P T R I A Y 2 C T M F N V G A Y T N I Y F V L A T I R 3 A K G V C I F V W I L V F A Q T L P L 4 Y C I L I I I L P L V Y G I F C A G L L I 5 I L I I V V F V L C F T P Y H V A I I Q 6 F P D M C C N F N M L C V T F H L S I 7

GPCRdb(A)
GPCRdb(A)
GPR183
TM2
2x60 2.60x60 R87
TM3
3x33 3.33x33 Y112
3x37 3.37x37 Y116
TM4
4x56 4.56x56 Q162
ECL2
45x51 45.51x51 M182
TM5
5x40 5.39x40 L197
5x43 5.42x43 A200
5x44 5.43x44 C201
TM6
6x51 6.51x51 Y260
TM7
7x34 7.35x34 L290
7x38 7.39x38 V294