Structure information

CT receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7TYF

SPECIES

Homo sapiens

RESOLUTION

2.200

PREFERRED CHAIN

R

PUBLICATION DATE

March 23, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
amylin peptide W79 N-term aromatic (face-to-edge)
amylin peptide F99 N-term polar (hydrogen bond with backbone)
amylin peptide P100 N-term polar (hydrogen bond with backbone)
amylin peptide P100 N-term polar (hydrogen bond with backbone)
amylin peptide D101 N-term polar (charge-assisted hydrogen bond)
amylin peptide F102 N-term polar (hydrogen bond with backbone)
amylin peptide F102 N-term polar (hydrogen bond with backbone)
amylin peptide E123 N-term polar (charge-assisted hydrogen bond)
amylin peptide N124 N-term polar (hydrogen bond)
amylin peptide W128 N-term polar (hydrogen bond)
amylin peptide W128 N-term polar (hydrogen bond)
amylin peptide S129 N-term polar (hydrogen bond)
amylin peptide S129 N-term polar (hydrogen bond with backbone)
amylin peptide Y131 N-term hydrophobic
amylin peptide N135 N-term polar (hydrogen bond)
amylin peptide L142 1.33x33 TM1 hydrophobic
amylin peptide A145 1.36x36 TM1 hydrophobic
amylin peptide Y146 1.37x37 TM1 hydrophobic
amylin peptide Y149 1.40x40 TM1 hydrophobic
amylin peptide V206 ECL1 hydrophobic
amylin peptide P207 ECL1 polar (hydrogen bond with backbone)
amylin peptide G209 ECL1 polar (hydrogen bond with backbone)
amylin peptide M230 3.40x40 TM3 polar (hydrogen bond)
amylin peptide Y234 3.44x44 TM3 hydrophobic
amylin peptide L291 45.52x52 ECL2 polar (hydrogen bond with backbone)
amylin peptide V293 ECL2 polar (hydrogen bond with backbone)
amylin peptide H302 5.40x40 TM5 polar (hydrogen bond)
amylin peptide H302 5.40x40 TM5 polar (hydrogen bond)
amylin peptide H302 5.40x40 TM5 polar (hydrogen bond)
amylin peptide F356 6.53x53 TM6 hydrophobic
amylin peptide P360 ECL3 polar (hydrogen bond with backbone)
amylin peptide P360 ECL3 polar (hydrogen bond with backbone)
amylin peptide W361 ECL3 polar (hydrogen bond)
amylin peptide R362 ECL3 polar (hydrogen bond with backbone)
amylin peptide R362 ECL3 polar (hydrogen bond with backbone)
amylin peptide Y372 7.38x37 TM7 polar (hydrogen bond)
amylin peptide D373 7.39x38 TM7 polar (charge-assisted hydrogen bond)
amylin peptide H377 7.43x42 TM7 polar (hydrogen bond)

Ligands

amylin peptide

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Residue Diagrams

V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7
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ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E P R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
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Residue Table


GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x29 1.33x33 L142
1x32 1.36x36 A145
1x33 1.37x37 Y146
1x36 1.40x40 Y149
TM3
3x36 3.40x40 M230
3x40 3.44x44 Y234
ECL2
45x52 45.52x52 L291
TM5
5x44 5.40x40 H302
TM6
6x48 6.53x53 F356
TM7
7x33 7.38x37 Y372
7x34 7.39x38 D373
7x38 7.43x42 H377