Structure information

CT receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7TYH

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

R

PUBLICATION DATE

March 23, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
calcitonin human Y41 N-term aromatic (edge-to-face)
calcitonin human W79 N-term hydrophobic
calcitonin human P100 N-term polar (hydrogen bond with backbone)
calcitonin human D101 N-term polar (charge-assisted hydrogen bond)
calcitonin human D101 N-term polar (charge-assisted hydrogen bond)
calcitonin human Y131 N-term hydrophobic
calcitonin human L142 1.33x33 TM1 hydrophobic
calcitonin human A145 1.36x36 TM1 polar (hydrogen bond with backbone)
calcitonin human Y146 1.37x37 TM1 polar (hydrogen bond)
calcitonin human L148 1.39x39 TM1 hydrophobic
calcitonin human Y149 1.40x40 TM1 polar (hydrogen bond with backbone)
calcitonin human V206 ECL1 polar (hydrogen bond with backbone)
calcitonin human G209 ECL1 polar (hydrogen bond with backbone)
calcitonin human V212 ECL1 hydrophobic
calcitonin human L291 45.52x52 ECL2 hydrophobic
calcitonin human V293 ECL2 hydrophobic
calcitonin human H302 5.40x40 TM5 polar (hydrogen bond)
calcitonin human F356 6.53x53 TM6 polar (hydrogen bond with backbone)
calcitonin human F359 6.56x56 TM6 polar (hydrogen bond with backbone)
calcitonin human W361 ECL3 hydrophobic
calcitonin human R362 ECL3 polar (hydrogen bond with backbone)

Ligands

calcitonin human

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Residue Diagrams

V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7
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ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E P R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
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Residue Table


GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x29 1.33x33 L142
1x32 1.36x36 A145
1x33 1.37x37 Y146
1x35 1.39x39 L148
1x36 1.40x40 Y149
ECL2
45x52 45.52x52 L291
TM5
5x44 5.40x40 H302
TM6
6x48 6.53x53 F356
6x51 6.56x56 F359