Structure information

CT receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7TYN

SPECIES

Homo sapiens

RESOLUTION

2.600

PREFERRED CHAIN

R

PUBLICATION DATE

March 30, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Calcitonin salmon Y41 N-term hydrophobic
Calcitonin salmon W79 N-term hydrophobic
Calcitonin salmon P100 N-term polar (hydrogen bond with backbone)
Calcitonin salmon D101 N-term polar (charge-assisted hydrogen bond)
Calcitonin salmon D101 N-term polar (charge-assisted hydrogen bond)
Calcitonin salmon W128 N-term polar (hydrogen bond)
Calcitonin salmon S129 N-term polar (hydrogen bond with backbone)
Calcitonin salmon N135 N-term polar (hydrogen bond with backbone)
Calcitonin salmon L142 1.33x33 TM1 hydrophobic
Calcitonin salmon A145 1.36x36 TM1 hydrophobic
Calcitonin salmon Y146 1.37x37 TM1 polar (hydrogen bond)
Calcitonin salmon Y146 1.37x37 TM1 polar (hydrogen bond)
Calcitonin salmon Y149 1.40x40 TM1 hydrophobic
Calcitonin salmon V206 ECL1 hydrophobic
Calcitonin salmon L291 45.52x52 ECL2 hydrophobic
Calcitonin salmon S292 ECL2 polar (hydrogen bond)
Calcitonin salmon V293 ECL2 polar (hydrogen bond with backbone)
Calcitonin salmon E294 ECL2 polar (charge-assisted hydrogen bond)
Calcitonin salmon H302 5.40x40 TM5 polar (hydrogen bond)
Calcitonin salmon M306 5.44x44 TM5 hydrophobic
Calcitonin salmon F356 6.53x53 TM6 polar (hydrogen bond with backbone)
Calcitonin salmon P360 ECL3 polar (hydrogen bond with backbone)
Calcitonin salmon W361 ECL3 hydrophobic
Calcitonin salmon R362 ECL3 polar (hydrogen bond with backbone)

Ligands

Calcitonin salmon

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Residue Diagrams

V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7
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ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E P R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
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Residue Table


GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x29 1.33x33 L142
1x32 1.36x36 A145
1x33 1.37x37 Y146
1x36 1.40x40 Y149
ECL2
45x52 45.52x52 L291
TM5
5x44 5.40x40 H302
5x48 5.44x44 M306
TM6
6x48 6.53x53 F356