Structure information

CT receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7TZF

SPECIES

Homo sapiens

RESOLUTION

2.400

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIENCE.ABM9609

PUBLICATION DATE

March 23, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
amylin peptide D77 N-term Van der Waals
amylin peptide G78 N-term Van der Waals
amylin peptide W79 N-term aromatic (face-to-edge)
amylin peptide W79 N-term Van der Waals
amylin peptide D97 N-term Van der Waals
amylin peptide F99 N-term hydrophobic
amylin peptide F99 N-term Van der Waals
amylin peptide P100 N-term polar (hydrogen bond with backbone)
amylin peptide P100 N-term Van der Waals
amylin peptide D101 N-term polar (charge-assisted hydrogen bond)
amylin peptide F102 N-term hydrophobic
amylin peptide F102 N-term Van der Waals
amylin peptide P104 N-term Van der Waals
amylin peptide H121 N-term Van der Waals
amylin peptide N124 N-term Van der Waals
amylin peptide N124 N-term polar (hydrogen bond)
amylin peptide R126 N-term polar (charge-assisted hydrogen bond)
amylin peptide W128 N-term polar (hydrogen bond)
amylin peptide W128 N-term polar (hydrogen bond)
amylin peptide S129 N-term polar (hydrogen bond with backbone)
amylin peptide S129 N-term Van der Waals
amylin peptide Y131 N-term Van der Waals
amylin peptide Y131 N-term hydrophobic
amylin peptide N135 N-term polar (hydrogen bond)
amylin peptide N135 N-term Van der Waals
amylin peptide K141 1.32x32 TM1 Van der Waals
amylin peptide L142 1.33x33 TM1 Van der Waals
amylin peptide L142 1.33x33 TM1 hydrophobic
amylin peptide A145 1.36x36 TM1 hydrophobic
amylin peptide A145 1.36x36 TM1 Van der Waals
amylin peptide Y146 1.37x37 TM1 hydrophobic
amylin peptide Y146 1.37x37 TM1 Van der Waals
amylin peptide V147 1.38x38 TM1 Van der Waals
amylin peptide V147 1.38x38 TM1 hydrophobic
amylin peptide L148 1.39x39 TM1 hydrophobic
amylin peptide L148 1.39x39 TM1 Van der Waals
amylin peptide Y149 1.40x40 TM1 hydrophobic
amylin peptide Y149 1.40x40 TM1 Van der Waals
amylin peptide Y150 1.41x41 TM1 Van der Waals
amylin peptide Y150 1.41x41 TM1 hydrophobic
amylin peptide L151 1.42x42 TM1 hydrophobic
amylin peptide L151 1.42x42 TM1 Van der Waals
amylin peptide V154 1.45x45 TM1 Van der Waals
amylin peptide V154 1.45x45 TM1 hydrophobic
amylin peptide L158 1.49x49 TM1 Van der Waals
amylin peptide L158 1.49x49 TM1 hydrophobic
amylin peptide V206 ECL1 hydrophobic
amylin peptide V206 ECL1 Van der Waals
amylin peptide P207 ECL1 Van der Waals
amylin peptide P207 ECL1 hydrophobic
amylin peptide G209 ECL1 polar (hydrogen bond with backbone)
amylin peptide G209 ECL1 Van der Waals
amylin peptide H226 3.36x36 TM3 Van der Waals
amylin peptide M230 3.40x40 TM3 polar (hydrogen bond)
amylin peptide Y234 3.44x44 TM3 hydrophobic
amylin peptide Y234 3.44x44 TM3 Van der Waals
amylin peptide L291 45.52x52 ECL2 Van der Waals
amylin peptide L291 45.52x52 ECL2 polar (hydrogen bond with backbone)
amylin peptide V293 ECL2 polar (hydrogen bond with backbone)
amylin peptide V293 ECL2 Van der Waals
amylin peptide E294 ECL2 polar (hydrogen bond with backbone)
amylin peptide E294 ECL2 Van der Waals
amylin peptide H296 ECL2 Van der Waals
amylin peptide Y299 5.37x38 TM5 polar (hydrogen bond)
amylin peptide Y299 5.37x38 TM5 Van der Waals
amylin peptide Y299 5.37x38 TM5 polar (hydrogen bond)
amylin peptide H302 5.40x40 TM5 polar (hydrogen bond)
amylin peptide F356 6.53x53 TM6 hydrophobic
amylin peptide F356 6.53x53 TM6 Van der Waals
amylin peptide P360 ECL3 Van der Waals
amylin peptide P360 ECL3 polar (hydrogen bond with backbone)
amylin peptide W361 ECL3 polar (hydrogen bond)
amylin peptide R362 ECL3 polar (hydrogen bond with backbone)
amylin peptide R362 ECL3 Van der Waals
amylin peptide Y372 7.38x37 TM7 Van der Waals
amylin peptide H377 7.43x42 TM7 Van der Waals
amylin peptide I380 7.46x45 TM7 Van der Waals
amylin peptide H381 7.47x46 TM7 Van der Waals
amylin peptide F382 7.48x47 TM7 Van der Waals
amylin peptide F382 7.48x47 TM7 hydrophobic
amylin peptide F385 7.51x51 TM7 hydrophobic

Ligands

amylin peptide

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Residue Diagrams

V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7
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ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E L R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
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Residue Table


GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x28 1.32x32 K141
1x29 1.33x33 L142
1x32 1.36x36 A145
1x33 1.37x37 Y146
1x34 1.38x38 V147
1x35 1.39x39 L148
1x36 1.40x40 Y149
1x37 1.41x41 Y150
1x38 1.42x42 L151
1x41 1.45x45 V154
1x45 1.49x49 L158
TM3
3x32 3.36x36 H226
3x36 3.40x40 M230
3x40 3.44x44 Y234
ECL2
45x52 45.52x52 L291
TM5
5x42 5.37x38 Y299
5x44 5.40x40 H302
TM6
6x48 6.53x53 F356
TM7
7x33 7.38x37 Y372
7x38 7.43x42 H377
7x41 7.46x45 I380
7x42 7.47x46 H381
7x43 7.48x47 F382
7x47 7.51x51 F385