Structure information

NTS1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7UL2

SPECIES

Homo sapiens

RESOLUTION

2.400

PREFERRED CHAIN

R

REFERENCE

10.1038/S41594-022-00859-8

PUBLICATION DATE

June 29, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
meclinertant I237 5.39x40 TM5 hydrophobic
meclinertant R322 6.54x54 TM6 polar (charge-assisted hydrogen bond)
meclinertant M325 6.57x57 TM6 Van der Waals
meclinertant M325 6.57x57 TM6 hydrophobic
meclinertant F326 6.58x58 TM6 Van der Waals
meclinertant F326 6.58x58 TM6 hydrophobic
meclinertant I329 6.61x61 TM6 Van der Waals
meclinertant W334 ECL3 Van der Waals
meclinertant W334 ECL3 hydrophobic
meclinertant Y339 7.28x27 TM7 hydrophobic
meclinertant Y339 7.28x27 TM7 Van der Waals
meclinertant Y342 7.31x30 TM7 aromatic (face-to-edge)
meclinertant Y342 7.31x30 TM7 Van der Waals
meclinertant H343 7.32x31 TM7 Van der Waals
meclinertant Y346 7.35x34 TM7 Van der Waals
meclinertant Y346 7.35x34 TM7 aromatic (edge-to-face)

Ligands

meclinertant

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Residue Diagrams

T N G V T G V V F L A L Y V A T V L V K 1 G S L A L S D L L T L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A V P M 4 N L V S I V V M P F I F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I T S S V Y F L A N T V M Y F Y 7
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ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G E Q N R S A D G Q H A G G L V C T P T I ECL2ICL3 Q V C T V G G E H S T F S M A I E ICL3ECL3 S D E Q W ECL3N-term M R L N S S A P G T P G T P A A D P F Q R A Q A G L E E A L L A P G F G N A S G N A S E R V L A A P S S E L D V N T N-termC-term P V W R R R R K R P A F S R K A D S V S S N H T L S S N A T R E T L Y C-term D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A V P M L F T M H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E Q G P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F L A L C F R H I T L A C
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Residue Table


GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM5
5x40 5.39x40 I237
TM6
6x54 6.54x54 R322
6x57 6.57x57 M325
6x58 6.58x58 F326
6x61 6.61x61 I329
TM7
7x27 7.28x27 Y339
7x30 7.31x30 Y342
7x31 7.32x31 H343
7x34 7.35x34 Y346