PDB
7UM5
Resolution
2.7 Å
Released
July 20, 2022
Receptor
5-HT5A
Class
A
Species
Homo sapiens
Ligand
5-CT
Function
Agonist
Reference
10.1038/S41594-022-00796-6

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Ligand Amino Acid Generic Number Segment Interaction Type
5-CT D121 3.32x32 TM3 polar (charge-assisted hydrogen bond)
5-CT V122 3.33x33 TM3 Van der Waals
5-CT V122 3.33x33 TM3 hydrophobic
5-CT C125 3.36x36 TM3 Van der Waals
5-CT T126 3.37x37 TM3 Van der Waals
5-CT T126 3.37x37 TM3 polar (hydrogen bond)
5-CT S204 5.42x43 TM5 polar (hydrogen bond)
5-CT S204 5.42x43 TM5 Van der Waals
5-CT F301 6.51x51 TM6 Van der Waals
5-CT F301 6.51x51 TM6 hydrophobic
5-CT F302 6.52x52 TM6 aromatic (edge-to-face)
5-CT F302 6.52x52 TM6 Van der Waals
5-CT E305 6.55x55 TM6 polar (charge-assisted hydrogen bond)
5-CT Y328 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R T F H ICL1ECL1 R R W Q L ECL1ICL2 H M E Y T ICL2ECL2 W G E T Y S E G S E E C Q V S R ECL2ICL3 V S P I S E A V E V K D S A K Q P Q M V F T V R H A T V T F Q P E G D ICL3ECL3 S C D I ECL3N-term M D L P V N L T S F S L S T P S P L E T N H S L G K D D L R P S S P L N-termC-term S R Q H C-term L S V F G V L I L T L L G F L V A A T F A W N L L V L A T I L R V R V P H N L V A S M A V S D V L V A A L V M P L S L V H E L S G G R R L C Q L W I A C D V L C C T A S I W N V T A I A L D R Y W S I T R L R T R K C V S N V M I A L T W A L S A V I S L A P L L F G E P S Y A V F S T V G A F Y L P L C V V L F V Y W K I Y K A A K F R V G S R K T N S T W R E Q K E Q R A A L M V G I L I G V F V L C W I P F F L T E L I S P L C P A I W K S I F L W L G Y S N S F F N P L I Y T A F N K N F K N Y N S A F F
Helix box plot — Download: PNG | SVG L N W A F T A A V L F G L L T L I L V G 1 A S M A V S D V L V A L A V M P L S L V H 2 A T V N W I S A T C C L V D C A I W L Q 3 S N V M I A L T W A L S A V I S L A P L 4 Y V F L V V C L P L Y F A G V T S F V A Y 5 G I L I G V F V L C W I P F F L T E L I 6 L P N F F S N S Y G L W L F I S K W I 7

GPCRdb(A)
GPCRdb(A)
5-HT5A receptor
TM3
3x32 3.32x32 D121
3x33 3.33x33 V122
3x36 3.36x36 C125
3x37 3.37x37 T126
TM5
5x43 5.42x43 S204
TM6
6x51 6.51x51 F301
6x52 6.52x52 F302
6x55 6.55x55 E305
TM7
7x42 7.43x42 Y328