Structure information

glucagon receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7V35

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-28683-0

PUBLICATION DATE

March 2, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Peptide-20 V28 N-term hydrophobic
Peptide-20 M29 N-term hydrophobic
Peptide-20 L32 N-term hydrophobic
Peptide-20 W36 N-term aromatic (face-to-edge)
Peptide-20 Y65 N-term hydrophobic
Peptide-20 P114 N-term polar (hydrogen bond with backbone)
Peptide-20 P114 N-term Van der Waals
Peptide-20 R116 N-term Van der Waals
Peptide-20 Q131 1.29x29 TM1 Van der Waals
Peptide-20 A135 1.33x33 TM1 hydrophobic
Peptide-20 A135 1.33x33 TM1 Van der Waals
Peptide-20 Y138 1.36x36 TM1 hydrophobic
Peptide-20 Y138 1.36x36 TM1 Van der Waals
Peptide-20 S139 1.37x37 TM1 polar (hydrogen bond)
Peptide-20 S139 1.37x37 TM1 Van der Waals
Peptide-20 F141 1.39x39 TM1 hydrophobic
Peptide-20 Q142 1.40x40 TM1 polar (hydrogen bond)
Peptide-20 V143 1.41x41 TM1 Van der Waals
Peptide-20 Y145 1.43x43 TM1 Van der Waals
Peptide-20 Y145 1.43x43 TM1 hydrophobic
Peptide-20 T146 1.44x44 TM1 Van der Waals
Peptide-20 L192 2.65x65 TM2 hydrophobic
Peptide-20 L192 2.65x65 TM2 Van der Waals
Peptide-20 L198 2.71x71 TM2 Van der Waals
Peptide-20 L198 2.71x71 TM2 hydrophobic
Peptide-20 R199 2.72x72 TM2 polar (charge-assisted hydrogen bond)
Peptide-20 Y202 2.75x75 TM2 Van der Waals
Peptide-20 Y202 2.75x75 TM2 polar (hydrogen bond with backbone)
Peptide-20 K205 ECL1 Van der Waals
Peptide-20 I206 ECL1 Van der Waals
Peptide-20 I206 ECL1 polar (hydrogen bond with backbone)
Peptide-20 G207 ECL1 Van der Waals
Peptide-20 D208 ECL1 Van der Waals
Peptide-20 D209 ECL1 Van der Waals
Peptide-20 Q232 3.37x37 TM3 polar (hydrogen bond)
Peptide-20 I235 3.40x40 TM3 Van der Waals
Peptide-20 I235 3.40x40 TM3 hydrophobic
Peptide-20 T296 45.52x52 ECL2 Van der Waals
Peptide-20 S297 ECL2 Van der Waals
Peptide-20 S297 ECL2 polar (hydrogen bond)
Peptide-20 N298 ECL2 Van der Waals
Peptide-20 N298 ECL2 polar (hydrogen bond)
Peptide-20 W304 5.36x37 TM5 hydrophobic
Peptide-20 W304 5.36x37 TM5 Van der Waals
Peptide-20 D370 ECL3 Van der Waals
Peptide-20 R378 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Peptide-20 L382 7.39x38 TM7 Van der Waals
Peptide-20 L382 7.39x38 TM7 hydrophobic
Peptide-20 D385 7.42x41 TM7 Van der Waals
Peptide-20 L386 7.43x42 TM7 hydrophobic
Peptide-20 L386 7.43x42 TM7 Van der Waals

Ligands

Peptide-20

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Residue Diagrams

L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7
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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
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Residue Table


GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM1
1x25 1.29x29 Q131
1x29 1.33x33 A135
1x32 1.36x36 Y138
1x33 1.37x37 S139
1x35 1.39x39 F141
1x36 1.40x40 Q142
1x37 1.41x41 V143
1x39 1.43x43 Y145
1x40 1.44x44 T146
TM2
2x58 2.65x65 L192
2x64 2.71x71 L198
2x65 2.72x72 R199
2x68 2.75x75 Y202
TM3
3x33 3.37x37 Q232
3x36 3.40x40 I235
ECL2
45x52 45.52x52 T296
TM5
5x41 5.36x37 W304
TM7
7x30 7.35x34 R378
7x34 7.39x38 L382
7x37 7.42x41 D385
7x38 7.43x42 L386