Structure information

GHRH receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7V9M

SPECIES

Homo sapiens

RESOLUTION

3.290

PREFERRED CHAIN

R

REFERENCE

10.1073/PNAS.2106606118

PUBLICATION DATE

Oct. 20, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Somatoliberin L55 1.29x29 TM1 polar (hydrogen bond with backbone)
Somatoliberin L55 1.29x29 TM1 Van der Waals
Somatoliberin E58 1.32x32 TM1 Van der Waals
Somatoliberin E59 1.33x33 TM1 Van der Waals
Somatoliberin F62 1.36x36 TM1 Van der Waals
Somatoliberin F62 1.36x36 TM1 hydrophobic
Somatoliberin V65 1.39x39 TM1 hydrophobic
Somatoliberin K66 1.40x40 TM1 Van der Waals
Somatoliberin Y69 1.43x43 TM1 Van der Waals
Somatoliberin Y69 1.43x43 TM1 polar (hydrogen bond)
Somatoliberin K118 2.67x67 TM2 polar (charge-assisted hydrogen bond)
Somatoliberin L122 2.71x71 TM2 Van der Waals
Somatoliberin H124 ECL1 aromatic (face-to-edge)
Somatoliberin H124 ECL1 Van der Waals
Somatoliberin H124 ECL1 polar (hydrogen bond)
Somatoliberin D129 ECL1 polar (charge-assisted hydrogen bond)
Somatoliberin H130 ECL1 Van der Waals
Somatoliberin S145 3.36x36 TM3 Van der Waals
Somatoliberin S145 3.36x36 TM3 polar (hydrogen bond)
Somatoliberin H146 3.37x37 TM3 polar (hydrogen bond)
Somatoliberin H146 3.37x37 TM3 aromatic (face-to-edge)
Somatoliberin H146 3.37x37 TM3 Van der Waals
Somatoliberin T149 3.40x40 TM3 Van der Waals
Somatoliberin D210 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
Somatoliberin L211 ECL2 Van der Waals
Somatoliberin L211 ECL2 hydrophobic
Somatoliberin W218 5.36x37 TM5 Van der Waals
Somatoliberin W218 5.36x37 TM5 hydrophobic
Somatoliberin I225 5.43x43 TM5 Van der Waals
Somatoliberin I225 5.43x43 TM5 hydrophobic
Somatoliberin L290 7.35x34 TM7 Van der Waals
Somatoliberin L290 7.35x34 TM7 hydrophobic
Somatoliberin L294 7.39x38 TM7 hydrophobic
Somatoliberin L294 7.39x38 TM7 Van der Waals
Somatoliberin E297 7.42x41 TM7 polar (charge-assisted hydrogen bond)
Somatoliberin L298 7.43x42 TM7 hydrophobic
Somatoliberin L298 7.43x42 TM7 Van der Waals

Ligands

Somatoliberin

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Residue Diagrams

F L A V I S I S H G V T Y I I K V T S F 1 T Q L F T T F I L K A G A V F L K D A A 2 A L L W S F N T M T A F H S A A V S V K 3 A F W W L V L G A W G L P V L F T G T W V 4 F L G F N V G V S L V I P G K I I W W 5 L F L I P L F G I H Y I I F N F L 6 I A V I F G Q F S G L G L E L P L R I 7
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ICL1 R R L H ICL1ECL1 H S D D T D H C S F S ECL1ICL2 T S P S S ICL2ECL2 D I A C W D L D D T S P Y ECL2ICL3 E P A Q G S L ICL3ECL3 P D N A ECL3N-term M D R R M W G A H V F C V L S P L P T V L G H M H P E C D F I T Q L R E D E S A C L Q A A E E M P N T T L G C P A T W D G L L C W P T A G S G E W V T L P C P D F F S H F S S E S G A V K R D C T I T G W S E P F P P Y P V A C P V P N-termC-term A K W T T P S R S A A K V L T S M C C-term L E L L A E E E S Y F S T V K I I Y T V G H S I S I V A L F V A I T I L V A L C P R N Y V H T Q L F T T F I L K A G A V F L K D A A L F T V L C K V S V A A S H F A T M T N F S W L L A E A V Y L N C L L A S R R A F W W L V L A G W G L P V L F T G T W V S C K L A F E W W I I K G P I V L S V G V N F G L F L N I I R I L V R K L H T Q S Q Y W R L S K S T L F L I P L F G I H Y I I F N F L G L G I R L P L E L G L G S F Q G F I V A I L Y C F L N Q E I S R H D P A W R V R T E K W H G E L L P T R
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Residue Table


GPCRdb(A)
GPCRdb(B)
GHRH receptor
TM1
1x25 1.29x29 L119
1x28 1.32x32 E122
1x29 1.33x33 E123
1x32 1.36x36 F126
1x35 1.39x39 V129
1x36 1.40x40 K130
1x39 1.43x43 Y133
TM2
2x60 2.67x67 K182
2x64 2.71x71 L186
TM3
3x32 3.36x36 S209
3x33 3.37x37 H210
3x36 3.40x40 T213
ECL2
45x52 45.52x52 D274
TM5
5x41 5.36x37 W282
5x47 5.43x43 I289
TM7
7x30 7.35x34 L354
7x34 7.39x38 L358
7x37 7.42x41 E361
7x38 7.43x42 L362