Structure information

GIP receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7VAB

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

PUBLICATION DATE

March 2, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
tirzepatide Q30 polar (hydrogen bond with backbone)
tirzepatide Q30 polar (hydrogen bond with backbone)
tirzepatide L35 hydrophobic
tirzepatide W39 aromatic (face-to-edge)
tirzepatide L134 1.36x36 TM1 hydrophobic
tirzepatide Y141 1.43x43 TM1 aromatic (edge-to-face)
tirzepatide Y145 1.47x47 TM1 polar (charge-assisted hydrogen bond)
tirzepatide R190 2.67x67 TM2 polar (charge-assisted hydrogen bond)
tirzepatide Q224 3.37x37 TM3 polar (hydrogen bond)
tirzepatide E288 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
tirzepatide R289 ECL2 polar (charge-charge)
tirzepatide N290 ECL2 polar (hydrogen bond with backbone)
tirzepatide W296 5.36x37 TM5 hydrophobic
tirzepatide I303 5.43x43 TM5 hydrophobic
tirzepatide E354 6.53x53 TM6 polar (charge-charge)
tirzepatide L374 7.39x38 TM7 hydrophobic
tirzepatide I378 7.43x42 TM7 hydrophobic

Ligands

tirzepatide

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Residue Diagrams

L L T A L S L S Y G V T Y M V Q L R E L 1 I N L F T S F M L R A A A I L S R D R L 2 V L L W T Y N A G V C Y Q T V I Q A T R 3 H F R Y Y L L G L W G A P A L F V I P W V 4 F I L F N I L I T M L I P T R I I W W I A 5 L T L V P L L G V H E V V F A P V 6 V S V L F G Q F S S L F I E F G L K A 7
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ICL1 R R L H ICL1ECL1 P R P G P Y L G D Q A L A L W N ECL1ICL2 V G G S E E G ICL2ECL2 N T Q C W E R N E V ECL2ICL3 Q M ICL3ECL3 T E E Q A R ECL3N-term M T T S P I L Q L L L R L S L C G L L L Q R A E T G S K G Q T A G E L Y Q R W E R Y R R E C Q E T L A A A E P P S G L A C N G S F D M Y V C W D Y A A P N A T A R A S C P W Y L P W H H H V A A G F V L R Q C G S D G Q W G L W R D H T Q C E N P E K N-termC-term Q L P E R A F R A L P S G S G P G E V P T S R G L S S G T L P G P G N E A S R E L E S Y C C-term N E A F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F C T R N Y I H I N L F T S F M L R A A A I L S R D R L L Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R R C R D Y R L R L A R S T L T L V P L L G V H E V V F A P V G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E I R R C R L G E E V Q S E G W H H R R S L Q R
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Residue Table


GPCRdb(A)
GPCRdb(B)
GIP receptor
TM1
1x32 1.36x36 L134
1x39 1.43x43 Y141
1x43 1.47x47 Y145
TM2
2x60 2.67x67 R190
TM3
3x33 3.37x37 Q224
ECL2
45x52 45.52x52 E288
TM5
5x41 5.36x37 W296
5x47 5.43x43 I303
TM6
6x48 6.53x53 E354
TM7
7x34 7.39x38 L374
7x38 7.43x42 I378