PDB
7VGZ
Resolution
3.3 Å
Released
March 2, 2022
Receptor
MT1
Class
A
Species
Homo sapiens
Ligand
ramelteon
Function
Agonist
Reference
10.1038/S41467-022-28111-3

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Ligand Amino Acid Generic Number Segment Interaction Type
ramelteon V111 3.36x36 TM3 hydrophobic
ramelteon I112 3.37x37 TM3 hydrophobic
ramelteon F179 45.52x52 ECL2 hydrophobic
ramelteon V191 5.42x43 TM5 hydrophobic
ramelteon L254 6.51x51 TM6 polar (hydrogen bond with backbone)
ramelteon L254 6.51x51 TM6 Van der Waals
ramelteon N255 6.52x52 TM6 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K K L R ICL1ECL1 G W N L ECL1ICL2 S L K Y D K L Y ICL2ECL2 T L Q Y D P R I Y S C T F A Q S V ECL2ICL3 K P D R K ICL3ECL3 P A S M V P R I ECL3N-term M Q G N G S A L P N A S Q P V L R G D G A R N-termC-term A R V F F V D S S N D V A D R V K W K P S P L M T N N N V V K V D S V C-term P S W L A S A L A C V L I F T I V V D I L G N L L V I L S V Y R N N A G N I F V V S L A V A D L V V A I Y P Y P L V L M S I F N N G Y L H C Q V S G F L M G L S V I G S I F N I T G I A I N R Y C Y I C H S S K N S L C Y V L L I W L L T L A A V L P N L R A G S S A Y T I A V V V F H F L V P M I I V I F C Y L R I W I L V L Q V R Q R V P K L K P Q D F R N F V T M F V V F V L F A I C W A P L N F I G L A V A S D P E W L F V A S Y Y M A Y F N S C L N A I I Y G L L N Q N Y R R L C T F R K E I I V S
Helix box plot — Download: PNG | SVG L N G L I D V V I T F I L V C A L A S A 1 V S L A V A D L V V A Y I P Y P L V L M S 2 G T I N F I S G I V S L G M L F G S V Q 3 S L C Y V L L I W L L T L A A V L P N 4 Y C F I V I I M P V L F H F V V V A I T Y 5 F V V F V L F A I C W A P L N F I G L A 6 I A N L C S N F Y A M Y Y S A V F L W 7

GPCRdb(A)
GPCRdb(A)
MT1 receptor
TM3
3x36 3.36x36 V111
3x37 3.37x37 I112
ECL2
45x52 45.52x52 F179
TM5
5x43 5.42x43 V191
TM6
6x51 6.51x51 L254
6x52 6.52x52 N255