Structure information

MT1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7VGZ

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

B

REFERENCE

10.1038/S41467-022-28111-3

PUBLICATION DATE

March 2, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ramelteon V111 3.36x36 TM3 hydrophobic
ramelteon I112 3.37x37 TM3 hydrophobic
ramelteon F179 45.52x52 ECL2 hydrophobic
ramelteon V191 5.42x43 TM5 hydrophobic
ramelteon L254 6.51x51 TM6 polar (hydrogen bond with backbone)
ramelteon L254 6.51x51 TM6 Van der Waals
ramelteon N255 6.52x52 TM6 Van der Waals

Ligands

ramelteon

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Residue Diagrams

L N G L I D V V I T F I L V C A L A S A 1 V S L A V A D L V V A Y I P Y P L V L M S 2 G T I N F I S G I V S L G M L F G S V Q 3 S L C Y V L L I W L L T L A A V L P N 4 Y C F I V I I M P V L F H F V V V A I T Y 5 F V V F V L F A I C W A P L N F I G L A 6 I A N L C S N F Y A M Y Y S A V F L W 7
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ICL1 K K L R ICL1ECL1 G W N L ECL1ICL2 S L K Y D K L Y ICL2ECL2 T L Q Y D P R I Y S C T F A Q S V ECL2ICL3 K P D R K ICL3ECL3 P A S M V P R I ECL3N-term M Q G N G S A L P N A S Q P V L R G D G A R N-termC-term A R V F F V D S S N D V A D R V K W K P S P L M T N N N V V K V D S V C-term P S W L A S A L A C V L I F T I V V D I L G N L L V I L S V Y R N N A G N I F V V S L A V A D L V V A I Y P Y P L V L M S I F N N G Y L H C Q V S G F L M G L S V I G S I F N I T G I A I N R Y C Y I C H S S K N S L C Y V L L I W L L T L A A V L P N L R A G S S A Y T I A V V V F H F L V P M I I V I F C Y L R I W I L V L Q V R Q R V P K L K P Q D F R N F V T M F V V F V L F A I C W A P L N F I G L A V A S D P E W L F V A S Y Y M A Y F N S C L N A I I Y G L L N Q N Y R R L C T F R K E I I V S
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Residue Table


GPCRdb(A)
GPCRdb(A)
MT1 receptor
TM3
3x36 3.36x36 V111
3x37 3.37x37 I112
ECL2
45x52 45.52x52 F179
TM5
5x43 5.42x43 V191
TM6
6x51 6.51x51 L254
6x52 6.52x52 N255