Structure information

5-HT2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7VOD

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

A

REFERENCE

10.1038/S41593-021-00971-W

PUBLICATION DATE

Dec. 22, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
cariprazine W151 3.28x28 TM3 hydrophobic
cariprazine D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
cariprazine S159 3.36x36 TM3 Van der Waals
cariprazine L228 45.51x51 ECL2 Van der Waals
cariprazine L228 45.51x51 ECL2 hydrophobic
cariprazine F243 5.47x47 TM5 hydrophobic
cariprazine F243 5.47x47 TM5 Van der Waals
cariprazine F332 6.44x44 TM6 hydrophobic
cariprazine F332 6.44x44 TM6 Van der Waals
cariprazine V333 6.45x45 TM6 Van der Waals
cariprazine V333 6.45x45 TM6 hydrophobic
cariprazine W336 6.48x48 TM6 hydrophobic
cariprazine W336 6.48x48 TM6 Van der Waals
cariprazine F339 6.51x51 TM6 hydrophobic
cariprazine F339 6.51x51 TM6 Van der Waals
cariprazine F340 6.52x52 TM6 hydrophobic
cariprazine F340 6.52x52 TM6 Van der Waals
cariprazine V366 7.39x38 TM7 Van der Waals

Ligands

cariprazine

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Residue Diagrams

I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7
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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x28 3.28x28 W151
3x32 3.32x32 D155
3x36 3.36x36 S159
ECL2
45x51 45.51x51 L228
TM5
5x47 5.47x47 F243
TM6
6x44 6.44x44 F332
6x45 6.45x45 V333
6x48 6.48x48 W336
6x51 6.51x51 F339
6x52 6.52x52 F340
TM7
7x38 7.39x38 V366