Structure information

MRGPRX2

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7VV4

SPECIES

Homo sapiens

RESOLUTION

2.970

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

Dec. 1, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Cortistatin 14 E164 4.60x60 TM4 polar (charge-charge)
Cortistatin 14 C168 4.64x64 TM4 polar (hydrogen bond with backbone)
Cortistatin 14 F170 ECL2 hydrophobic
Cortistatin 14 S177 5.33x33 TM5 polar (hydrogen bond with backbone)
Cortistatin 14 S177 5.33x33 TM5 polar (hydrogen bond)
Cortistatin 14 D184 5.40x40 TM5 polar (charge-charge)
Cortistatin 14 W243 6.55x55 TM6 hydrophobic
Cortistatin 14 F257 7.31x30 TM7 hydrophobic

Ligands

Cortistatin 14

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Residue Diagrams

G N G V L G V L A I F L I L F V P I L T 1 L S L A G A D F L F L C F Q I I N C L V 2 T S L M S L G A L Y A C T M V T T F F S 3 S A V V C V L L W A L S L L L S I L E G 4 S S G C L V M F L F I L W A A T I F D F 5 L L T V L V F L L C G L P F G I Q W F L 6 I P N A S S N L S S L V V S V P H I H 7
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ICL1 R R ICL1ECL1 I S I N F ECL1ICL2 P I W Y R C R R ICL2ECL2 G F L F S D G ECL2ICL3 S R G L ICL3ECL3 K D S D V ECL3N-term M D P T T P A W G T E S T T V N G N D Q A L L L L C G K E N-termC-term R K Q W R L Q Q P I L K L A L Q R A L Q D I A E V D H S E G C F R Q G T P E M S R S S L V C-term T L I P V F L I L F I A L V G L V G N G F V L W L L G F R M N A F S V Y V L S L A G A D F L F L C F Q I I N C L V Y L S N F F C S P S F F T T V M T C A Y L A G L S M L S T V S T E R C L S V L W P R H L S A V V C V L L W A L S L L L S I L E G K F C D S G W C Q T F D F I T A A W L I F L F M V L C G S S L A L L V R I L C G P L T R L Y L T I L L T V L V F L L C G L P F G I Q W F L I L W I W L F C H I H P V S V V L S S L N S S A N P I I Y F F V G S F
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Residue Table


GPCRdb(A)
GPCRdb(A)
MRGPRX2
TM4
4x60 4.60x60 E164
4x64 4.64x64 C168
TM5
5x33 5.33x33 S177
5x40 5.40x40 D184
TM6
6x55 6.55x55 W243
TM7
7x30 7.31x30 F257