Structure information

PTH1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7VVO

SPECIES

Homo sapiens

RESOLUTION

4.100

PREFERRED CHAIN

R

REFERENCE

10.1016/J.MOLCEL.2022.07.003

PUBLICATION DATE

Aug. 3, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Parathyroid hormone Y195 1.47x47 TM1 Van der Waals
Parathyroid hormone Y195 1.47x47 TM1 polar (hydrogen bond)
Parathyroid hormone I237 2.64x64 TM2 hydrophobic
Parathyroid hormone I237 2.64x64 TM2 Van der Waals
Parathyroid hormone F288 3.36x36 TM3 Van der Waals
Parathyroid hormone F288 3.36x36 TM3 hydrophobic
Parathyroid hormone L289 3.37x37 TM3 Van der Waals
Parathyroid hormone L292 3.40x40 TM3 hydrophobic
Parathyroid hormone L292 3.40x40 TM3 Van der Waals
Parathyroid hormone Y296 3.44x44 TM3 Van der Waals
Parathyroid hormone Y296 3.44x44 TM3 hydrophobic
Parathyroid hormone Q364 5.40x40 TM5 Van der Waals
Parathyroid hormone F424 6.56x56 TM6 Van der Waals
Parathyroid hormone F424 6.56x56 TM6 polar (hydrogen bond with backbone)
Parathyroid hormone M425 6.57x57 TM6 Van der Waals
Parathyroid hormone M425 6.57x57 TM6 polar (hydrogen bond with backbone)
Parathyroid hormone T427 ECL3 polar (hydrogen bond with backbone)
Parathyroid hormone T427 ECL3 Van der Waals
Parathyroid hormone E444 7.42x41 TM7 Van der Waals

Ligands

Parathyroid hormone

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Residue Diagrams

T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7
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ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
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Residue Table


GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x43 1.47x47 Y195
TM2
2x57 2.64x64 I237
TM3
3x32 3.36x36 F288
3x33 3.37x37 L289
3x36 3.40x40 L292
3x40 3.44x44 Y296
TM5
5x44 5.40x40 Q364
TM6
6x51 6.56x56 F424
6x52 6.57x57 M425
TM7
7x37 7.42x41 E444