Ligand
Function
Agonist
Reference
| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| Elabela/Toddler-32 (Human) | Y35 | 1.39x39 | TM1 | hydrophobic |
| Elabela/Toddler-32 (Human) | W85 | 2.60x60 | TM2 | aromatic (face-to-edge) |
| Elabela/Toddler-32 (Human) | T89 | 2.64x64 | TM2 | polar (hydrogen bond) |
| Elabela/Toddler-32 (Human) | T89 | 2.64x64 | TM2 | Van der Waals |
| Elabela/Toddler-32 (Human) | T89 | 2.64x64 | TM2 | polar (hydrogen bond with backbone) |
| Elabela/Toddler-32 (Human) | Y93 | ECL1 | Van der Waals | |
| Elabela/Toddler-32 (Human) | Y93 | ECL1 | polar (hydrogen bond) | |
| Elabela/Toddler-32 (Human) | I109 | 3.32x32 | TM3 | hydrophobic |
| Elabela/Toddler-32 (Human) | I109 | 3.32x32 | TM3 | Van der Waals |
| Elabela/Toddler-32 (Human) | F110 | 3.33x33 | TM3 | hydrophobic |
| Elabela/Toddler-32 (Human) | F110 | 3.33x33 | TM3 | Van der Waals |
| Elabela/Toddler-32 (Human) | R168 | ECL2 | polar (charge-assisted hydrogen bond) | |
| Elabela/Toddler-32 (Human) | C181 | 45.50x50 | ECL2 | Van der Waals |
| Elabela/Toddler-32 (Human) | Y182 | 45.51x51 | ECL2 | Van der Waals |
| Elabela/Toddler-32 (Human) | Y182 | 45.51x51 | ECL2 | polar (hydrogen bond) |
| Elabela/Toddler-32 (Human) | Y264 | 6.51x51 | TM6 | polar (hydrogen bond) |
| Elabela/Toddler-32 (Human) | Y264 | 6.51x51 | TM6 | Van der Waals |
| Elabela/Toddler-32 (Human) | F291 | 7.35x34 | TM7 | hydrophobic |
| Elabela/Toddler-32 (Human) | F291 | 7.35x34 | TM7 | Van der Waals |
| Elabela/Toddler-32 (Human) | P292 | 7.36x35 | TM7 | hydrophobic |
| Elabela/Toddler-32 (Human) | T295 | 7.39x38 | TM7 | Van der Waals |
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|
GPCRdb(A)
|
GPCRdb(A)
|
apelin receptor
|
|---|---|---|
| TM1 | ||
| 1x39 | 1.39x39 | Y35 |
| TM2 | ||
| 2x60 | 2.60x60 | W85 |
| 2x64 | 2.64x64 | T89 |
| TM3 | ||
| 3x32 | 3.32x32 | I109 |
| 3x33 | 3.33x33 | F110 |
| ECL2 | ||
| 45x50 | 45.50x50 | C181 |
| 45x51 | 45.51x51 | Y182 |
| TM6 | ||
| 6x51 | 6.51x51 | Y264 |
| TM7 | ||
| 7x34 | 7.35x34 | F291 |
| 7x35 | 7.36x35 | P292 |
| 7x38 | 7.39x38 | T295 |