Structure information

apelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7W0N

SPECIES

Homo sapiens

RESOLUTION

4.210

PREFERRED CHAIN

R

REFERENCE

10.1038/S41594-022-00797-5

PUBLICATION DATE

July 27, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Apelin receptor early endogenous ligand Y35 1.39x39 TM1 hydrophobic
Apelin receptor early endogenous ligand W85 2.60x60 TM2 aromatic (face-to-edge)
Apelin receptor early endogenous ligand T89 2.64x64 TM2 polar (hydrogen bond)
Apelin receptor early endogenous ligand T89 2.64x64 TM2 Van der Waals
Apelin receptor early endogenous ligand T89 2.64x64 TM2 polar (hydrogen bond with backbone)
Apelin receptor early endogenous ligand Y93 ECL1 Van der Waals
Apelin receptor early endogenous ligand Y93 ECL1 polar (hydrogen bond)
Apelin receptor early endogenous ligand I109 3.32x32 TM3 hydrophobic
Apelin receptor early endogenous ligand I109 3.32x32 TM3 Van der Waals
Apelin receptor early endogenous ligand F110 3.33x33 TM3 hydrophobic
Apelin receptor early endogenous ligand F110 3.33x33 TM3 Van der Waals
Apelin receptor early endogenous ligand R168 ECL2 polar (charge-assisted hydrogen bond)
Apelin receptor early endogenous ligand C181 45.50x50 ECL2 Van der Waals
Apelin receptor early endogenous ligand Y182 45.51x51 ECL2 Van der Waals
Apelin receptor early endogenous ligand Y182 45.51x51 ECL2 polar (hydrogen bond)
Apelin receptor early endogenous ligand Y264 6.51x51 TM6 polar (hydrogen bond)
Apelin receptor early endogenous ligand Y264 6.51x51 TM6 Van der Waals
Apelin receptor early endogenous ligand F291 7.35x34 TM7 hydrophobic
Apelin receptor early endogenous ligand F291 7.35x34 TM7 Van der Waals
Apelin receptor early endogenous ligand P292 7.36x35 TM7 hydrophobic
Apelin receptor early endogenous ligand T295 7.39x38 TM7 Van der Waals

Ligands

Apelin receptor early endogenous ligand

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Residue Diagrams

G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7
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ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
apelin receptor
TM1
1x39 1.39x39 Y35
TM2
2x60 2.60x60 W85
2x64 2.64x64 T89
TM3
3x32 3.32x32 I109
3x33 3.33x33 F110
ECL2
45x50 45.50x50 C181
45x51 45.51x51 Y182
TM6
6x51 6.51x51 Y264
TM7
7x34 7.35x34 F291
7x35 7.36x35 P292
7x38 7.39x38 T295