PDB
7W0N
Resolution
4.2 Å
Released
July 27, 2022
Receptor
apelin
Class
A
Species
Homo sapiens
Ligand
Function
Elabela/Toddler-32 (Human)
Agonist
Reference
10.1038/S41594-022-00797-5

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Ligand Amino Acid Generic Number Segment Interaction Type
Elabela/Toddler-32 (Human) W24 N-term Van der Waals
Elabela/Toddler-32 (Human) I31 1.35x35 TM1 hydrophobic
Elabela/Toddler-32 (Human) Y35 1.39x39 TM1 hydrophobic
Elabela/Toddler-32 (Human) W85 2.60x60 TM2 hydrophobic
Elabela/Toddler-32 (Human) W85 2.60x60 TM2 aromatic (edge-to-face)
Elabela/Toddler-32 (Human) Y88 2.63x63 TM2 Van der Waals
Elabela/Toddler-32 (Human) T89 2.64x64 TM2 Van der Waals
Elabela/Toddler-32 (Human) D92 2.67x67 TM2 polar (charge-charge)
Elabela/Toddler-32 (Human) Y93 ECL1 Van der Waals
Elabela/Toddler-32 (Human) I109 3.32x32 TM3 hydrophobic
Elabela/Toddler-32 (Human) F110 3.33x33 TM3 Van der Waals
Elabela/Toddler-32 (Human) R168 ECL2 polar (hydrogen bond)
Elabela/Toddler-32 (Human) C181 45.50x50 ECL2 Van der Waals
Elabela/Toddler-32 (Human) Y182 45.51x51 ECL2 hydrophobic
Elabela/Toddler-32 (Human) Y264 6.51x51 TM6 polar (hydrogen bond)
Elabela/Toddler-32 (Human) M288 7.32x31 TM7 hydrophobic
Elabela/Toddler-32 (Human) F291 7.35x34 TM7 hydrophobic
Elabela/Toddler-32 (Human) P292 7.36x35 TM7 Van der Waals
Elabela/Toddler-32 (Human) T295 7.39x38 TM7 Van der Waals
Elabela/Toddler-32 (Human) Y299 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
Helix box plot — Download: PNG | SVG G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7

GPCRdb(A)
GPCRdb(A)
apelin receptor
TM1
1x35 1.35x35 I31
1x39 1.39x39 Y35
TM2
2x60 2.60x60 W85
2x63 2.63x63 Y88
2x64 2.64x64 T89
2x67 2.67x67 D92
TM3
3x32 3.32x32 I109
3x33 3.33x33 F110
ECL2
45x50 45.50x50 C181
45x51 45.51x51 Y182
TM6
6x51 6.51x51 Y264
TM7
7x31 7.32x31 M288
7x34 7.35x34 F291
7x35 7.36x35 P292
7x38 7.39x38 T295
7x42 7.43x42 Y299