PDB
7WC5
Resolution
3.2 Å
Released
Jan. 26, 2022
Receptor
5-HT2A
Class
A
Species
Homo sapiens
Ligand
psilocin
Function
Agonist
Reference
10.1126/SCIENCE.ABL8615

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Ligand Amino Acid Generic Number Segment Interaction Type
psilocin W151 3.28x28 TM3 aromatic (face-to-edge)
psilocin D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
psilocin V156 3.33x33 TM3 Van der Waals
psilocin L228 45.51x51 ECL2 hydrophobic
psilocin L228 45.51x51 ECL2 Van der Waals
psilocin F339 6.51x51 TM6 hydrophobic
psilocin F339 6.51x51 TM6 Van der Waals
psilocin N343 6.55x55 TM6 Van der Waals
psilocin N363 7.36x35 TM7 Van der Waals

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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
Helix box plot — Download: PNG | SVG I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7

GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x28 3.28x28 W151
3x32 3.32x32 D155
3x33 3.33x33 V156
ECL2
45x51 45.51x51 L228
TM6
6x51 6.51x51 F339
6x55 6.55x55 N343
TM7
7x35 7.36x35 N363