Structure information

5-HT2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7WC7

SPECIES

Homo sapiens

RESOLUTION

2.600

PREFERRED CHAIN

A

PUBLICATION DATE

Jan. 26, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
lisuride W151 3.28x28 TM3 hydrophobic
lisuride I152 3.29x29 TM3 hydrophobic
lisuride D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
lisuride V156 3.33x33 TM3 hydrophobic
lisuride V156 3.33x33 TM3 Van der Waals
lisuride S159 3.36x36 TM3 Van der Waals
lisuride C227 45.50x50 ECL2 Van der Waals
lisuride L229 45.52x52 ECL2 hydrophobic
lisuride L229 45.52x52 ECL2 Van der Waals
lisuride V235 5.39x40 TM5 Van der Waals
lisuride V235 5.39x40 TM5 hydrophobic
lisuride G238 5.42x43 TM5 polar (hydrogen bond with backbone)
lisuride G238 5.42x43 TM5 Van der Waals
lisuride S242 5.46x461 TM5 Van der Waals
lisuride W336 6.48x48 TM6 Van der Waals
lisuride W336 6.48x48 TM6 hydrophobic
lisuride F339 6.51x51 TM6 hydrophobic
lisuride F339 6.51x51 TM6 Van der Waals
lisuride F340 6.52x52 TM6 aromatic (edge-to-face)
lisuride F340 6.52x52 TM6 Van der Waals
lisuride V366 7.39x38 TM7 Van der Waals
lisuride V366 7.39x38 TM7 hydrophobic
lisuride Y370 7.43x42 TM7 Van der Waals

Ligands

lisuride

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Residue Diagrams

I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7
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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x28 3.28x28 W151
3x29 3.29x29 I152
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
ECL2
45x50 45.50x50 C227
45x52 45.52x52 L229
TM5
5x40 5.39x40 V235
5x43 5.42x43 G238
5x461 5.46x461 S242
TM6
6x48 6.48x48 W336
6x51 6.51x51 F339
6x52 6.52x52 F340
TM7
7x38 7.39x38 V366
7x42 7.43x42 Y370