Structure information

5-HT2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7WC8

SPECIES

Homo sapiens

RESOLUTION

2.450

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIENCE.ABL8615

PUBLICATION DATE

Jan. 26, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
LUMATEPERONE W151 3.28x28 TM3 hydrophobic
LUMATEPERONE D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
LUMATEPERONE V156 3.33x33 TM3 Van der Waals
LUMATEPERONE S159 3.36x36 TM3 Van der Waals
LUMATEPERONE T160 3.37x37 TM3 Van der Waals
LUMATEPERONE I163 3.40x40 TM3 hydrophobic
LUMATEPERONE I163 3.40x40 TM3 Van der Waals
LUMATEPERONE L228 45.51x51 ECL2 hydrophobic
LUMATEPERONE L228 45.51x51 ECL2 Van der Waals
LUMATEPERONE L229 45.52x52 ECL2 Van der Waals
LUMATEPERONE L229 45.52x52 ECL2 hydrophobic
LUMATEPERONE S242 5.46x461 TM5 Van der Waals
LUMATEPERONE F243 5.47x47 TM5 hydrophobic
LUMATEPERONE F243 5.47x47 TM5 Van der Waals
LUMATEPERONE F332 6.44x44 TM6 Van der Waals
LUMATEPERONE F332 6.44x44 TM6 hydrophobic
LUMATEPERONE W336 6.48x48 TM6 aromatic (face-to-edge)
LUMATEPERONE W336 6.48x48 TM6 Van der Waals
LUMATEPERONE F339 6.51x51 TM6 Van der Waals
LUMATEPERONE F339 6.51x51 TM6 aromatic (edge-to-face)
LUMATEPERONE F340 6.52x52 TM6 Van der Waals
LUMATEPERONE F340 6.52x52 TM6 aromatic (edge-to-face)
LUMATEPERONE N343 6.55x55 TM6 Van der Waals
LUMATEPERONE L362 7.35x34 TM7 Van der Waals
LUMATEPERONE V366 7.39x38 TM7 Van der Waals
LUMATEPERONE V366 7.39x38 TM7 hydrophobic
LUMATEPERONE Y370 7.43x42 TM7 Van der Waals

Ligands

LUMATEPERONE

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Residue Diagrams

I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7
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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x28 3.28x28 W151
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
3x37 3.37x37 T160
3x40 3.40x40 I163
ECL2
45x51 45.51x51 L228
45x52 45.52x52 L229
TM5
5x461 5.46x461 S242
5x47 5.47x47 F243
TM6
6x44 6.44x44 F332
6x48 6.48x48 W336
6x51 6.51x51 F339
6x52 6.52x52 F340
6x55 6.55x55 N343
TM7
7x34 7.35x34 L362
7x38 7.39x38 V366
7x42 7.43x42 Y370