PDB
7WJ5
Resolution
3.7 Å
Released
July 13, 2022
Receptor
SST2
Class
A
Species
Homo sapiens
Ligand
Function
SOMATOSTATIN
Agonist
Reference
10.7554/ELIFE.76823

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Ligand Amino Acid Generic Number Segment Interaction Type
SOMATOSTATIN F92 2.53x53 TM2 Van der Waals
SOMATOSTATIN L99 2.60x60 TM2 hydrophobic
SOMATOSTATIN Q102 2.63x63 TM2 Van der Waals
SOMATOSTATIN M119 3.29x29 TM3 Van der Waals
SOMATOSTATIN D122 3.32x32 TM3 polar (hydrogen bond)
SOMATOSTATIN D122 3.32x32 TM3 polar (charge-charge)
SOMATOSTATIN Q126 3.36x36 TM3 polar (hydrogen bond)
SOMATOSTATIN I177 4.60x61 TM4 hydrophobic
SOMATOSTATIN R184 ECL2 Van der Waals
SOMATOSTATIN N186 ECL2 Van der Waals
SOMATOSTATIN S192 ECL2 Van der Waals
SOMATOSTATIN C193 45.50x50 ECL2 polar (hydrogen bond with backbone)
SOMATOSTATIN T194 45.51x51 ECL2 Van der Waals
SOMATOSTATIN I195 45.52x52 ECL2 Van der Waals
SOMATOSTATIN W197 ECL2 Van der Waals
SOMATOSTATIN G202 5.32x33 TM5 Van der Waals
SOMATOSTATIN Y205 5.35x36 TM5 aromatic (face-to-face)
SOMATOSTATIN Y205 5.35x36 TM5 hydrophobic
SOMATOSTATIN F208 5.38x39 TM5 aromatic (edge-to-face)
SOMATOSTATIN F208 5.38x39 TM5 hydrophobic
SOMATOSTATIN T212 5.42x43 TM5 Van der Waals
SOMATOSTATIN F272 6.51x51 TM6 aromatic (pi-cation)
SOMATOSTATIN F272 6.51x51 TM6 hydrophobic
SOMATOSTATIN F272 6.51x51 TM6 aromatic (edge-to-face)
SOMATOSTATIN F275 6.54x54 TM6 Van der Waals
SOMATOSTATIN N276 6.55x55 TM6 polar (hydrogen bond)
SOMATOSTATIN N276 6.55x55 TM6 polar (hydrogen bond)
SOMATOSTATIN S279 6.58x58 TM6 polar (hydrogen bond)
SOMATOSTATIN V280 6.59x59 TM6 hydrophobic
SOMATOSTATIN P286 ECL3 hydrophobic
SOMATOSTATIN L290 7.31x30 TM7 hydrophobic
SOMATOSTATIN K291 7.32x31 TM7 Van der Waals
SOMATOSTATIN F294 7.35x34 TM7 hydrophobic
SOMATOSTATIN V298 7.39x38 TM7 Van der Waals
SOMATOSTATIN T301 7.42x41 TM7 Van der Waals
SOMATOSTATIN Y302 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
Helix box plot — Download: PNG | SVG T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7

GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM2
2x53 2.53x53 F92
2x60 2.60x60 L99
2x63 2.63x63 Q102
TM3
3x29 3.29x29 M119
3x32 3.32x32 D122
3x36 3.36x36 Q126
TM4
4x61 4.60x61 I177
ECL2
45x50 45.50x50 C193
45x51 45.51x51 T194
45x52 45.52x52 I195
TM5
5x33 5.32x33 G202
5x36 5.35x36 Y205
5x39 5.38x39 F208
5x43 5.42x43 T212
TM6
6x51 6.51x51 F272
6x54 6.54x54 F275
6x55 6.55x55 N276
6x58 6.58x58 S279
6x59 6.59x59 V280
TM7
7x30 7.31x30 L290
7x31 7.32x31 K291
7x34 7.35x34 F294
7x38 7.39x38 V298
7x41 7.42x41 T301
7x42 7.43x42 Y302