PDB
7WKD
Resolution
3.0 Å
Released
June 15, 2022
Receptor
TRH1
Class
A
Species
Homo sapiens
Ligand
Function
TRH (Human)
Agonist
Reference
10.1038/S41422-022-00641-X

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Ligand Amino Acid Generic Number Segment Interaction Type
TRH (Human) A78 2.57x56 TM2 Van der Waals
TRH (Human) T102 3.29x29 TM3 Van der Waals
TRH (Human) Q105 3.32x32 TM3 Van der Waals
TRH (Human) Y106 3.33x33 TM3 polar (hydrogen bond)
TRH (Human) Y106 3.33x33 TM3 hydrophobic
TRH (Human) I109 3.36x36 TM3 hydrophobic
TRH (Human) L164 ECL2 Van der Waals
TRH (Human) C179 45.50x50 ECL2 Van der Waals
TRH (Human) G180 45.51x51 ECL2 Van der Waals
TRH (Human) Y181 45.52x52 ECL2 Van der Waals
TRH (Human) R185 5.32x32 TM5 polar (hydrogen bond)
TRH (Human) Y192 5.39x39 TM5 Van der Waals
TRH (Human) Y282 6.51x51 TM6 hydrophobic
TRH (Human) Y282 6.51x51 TM6 polar (hydrogen bond)
TRH (Human) L285 6.54x54 TM6 hydrophobic
TRH (Human) V286 6.55x55 TM6 Van der Waals
TRH (Human) N289 6.58x58 TM6 polar (hydrogen bond)
TRH (Human) L302 7.35x34 TM7 hydrophobic
TRH (Human) R306 7.39x38 TM7 Van der Waals
TRH (Human) I309 7.42x41 TM7 hydrophobic
TRH (Human) Y310 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K H M R ICL1ECL1 G S W V Y ECL1ICL2 P I K A Q F L C ICL2ECL2 D L N I S T Y K D A I V I S C G Y K ECL2ICL3 N S K T W K N D S T H Q N T N L N V N T S N R C F ICL3ECL3 S S P F Q ECL3N-term M E N E T V S E L N Q T Q L Q P R A V V A N-termC-term C K Q K P T E K P A N Y S V A L N Y S V I K E S D H F S T E L D D I T V T D T Y L S A T K V S F D D T C L A S E V S F S Q S C-term L E Y Q V V T I L L V L I I C G L G I V G N I M V V L V V M R T T P T N C Y L V S L A V A D L M V L V A A G L P N I T D S I Y G Y V G C L C I T Y L Q Y L G I N A S S C S I T A F T I E R Y I A I C H T F S R A K K I I I F V W A F T S L Y C M L W F F L L I S R N Y Y S P I Y L M D F G V F Y V V P M I L A T V L Y G F I A R I L F L N P I P S D P K E N S T V S S R K Q V T K M L A V V V I L F A L L W M P Y R T L V V V N S F L E N W F L L F C R I C I Y L N S A I N P V I Y N L M S Q K F R K F R A A L C N
Helix box plot — Download: PNG | SVG I N G V I G L G C I I L V L L I T V V Q 1 V S L A V A D L M V L A V A G L P N I T D 2 A T I S C S S A N I G L Y Q L Y T I C L 3 A K K I I I F V W A F T S L Y C M L W F 4 Y L V T A L I M P V V Y F V G F D M L Y 5 A V V V I L F A L L W M P Y R T L V V V 6 V P N I A S N L Y I C I R C F L L F W 7

GPCRdb(A)
GPCRdb(A)
TRH1 receptor
TM2
2x56 2.57x56 A78
TM3
3x29 3.29x29 T102
3x32 3.32x32 Q105
3x33 3.33x33 Y106
3x36 3.36x36 I109
ECL2
45x50 45.50x50 C179
45x51 45.51x51 G180
45x52 45.52x52 Y181
TM5
5x32 5.32x32 R185
5x39 5.39x39 Y192
TM6
6x51 6.51x51 Y282
6x54 6.54x54 L285
6x55 6.55x55 V286
6x58 6.58x58 N289
TM7
7x34 7.35x34 L302
7x38 7.39x38 R306
7x41 7.42x41 I309
7x42 7.43x42 Y310