Structure information

GAL1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7WQ3

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-29072-3

PUBLICATION DATE

April 20, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
galanin E32 1.31x31 TM1 polar (charge-assisted hydrogen bond)
galanin Q92 2.61x60 TM2 polar (hydrogen bond)
galanin Q92 2.61x60 TM2 Van der Waals
galanin V95 2.64x63 TM2 Van der Waals
galanin V95 2.64x63 TM2 polar (hydrogen bond with backbone)
galanin Y96 2.65x64 TM2 hydrophobic
galanin Y96 2.65x64 TM2 Van der Waals
galanin L98 2.67x66 TM2 polar (hydrogen bond with backbone)
galanin L98 2.67x66 TM2 Van der Waals
galanin P99 ECL1 hydrophobic
galanin P99 ECL1 Van der Waals
galanin H112 3.29x29 TM3 polar (hydrogen bond)
galanin H112 3.29x29 TM3 Van der Waals
galanin F177 ECL2 Van der Waals
galanin F177 ECL2 hydrophobic
galanin R180 ECL2 Van der Waals
galanin F186 ECL2 Van der Waals
galanin F186 ECL2 hydrophobic
galanin C187 45.50x50 ECL2 Van der Waals
galanin W188 45.51x51 ECL2 polar (hydrogen bond)
galanin E189 45.52x52 ECL2 Van der Waals
galanin Q190 ECL2 Van der Waals
galanin A270 6.58x58 TM6 hydrophobic
galanin A270 6.58x58 TM6 Van der Waals
galanin F275 ECL3 hydrophobic
galanin F275 ECL3 Van der Waals
galanin L277 ECL3 hydrophobic
galanin L277 ECL3 Van der Waals
galanin F282 7.32x31 TM7 Van der Waals
galanin F282 7.32x31 TM7 hydrophobic
galanin R285 7.35x34 TM7 Van der Waals

Ligands

galanin

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Residue Diagrams

S N G L V G L A F I L G F V V L T V F N 1 L N L S I A D L A Y L F L C I P F Q A T V 2 A A L T F I S V L M S V T F F Y H I F K 3 A L L G V G C I W A L S I A M A S P V 4 Y C F C I L L L P L L Y G F V F T C V V Y 5 L V V V V V F G I S W L P H H I I H L W 6 I P N V S S N S Y A L C H A T I R F L 7
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ICL1 K P G K P R ICL1ECL1 P T W V L ECL1ICL2 S R R S S S L R ICL2ECL2 G L F H P R A S N Q T F C W E Q W P ECL2ICL3 K N M ICL3ECL3 V F P L ECL3N-term M E L A V G N L S E G N A S W P E P P A P E P G P L F G I N-termC-term C H I R K D S H L S D T K E S K S R I D T P P S T N C T H V C-term G V E N F V T L V V F G L I F A L G V L G N S L V I T V L A R S S T T N L F I L N L S I A D L A Y L L F C I P F Q A T V Y A L G A F I C K F I H Y F F T V S M L V S I F T L A A M S V D R Y V A I V H V S R N A L L G V G C I W A L S I A M A S P V A Y H Q D P R H K K A Y V V C T F V F G Y L L P L L L I C F C Y A K V L N H L H K K L S K K S E A S K K K T A Q T V L V V V V V F G I S W L P H H I I H L W A E F G T P A S F L F R I T A H C L A Y S N S S V N P I I Y A F L S E N Y K Q F R K A V F K
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Residue Table


GPCRdb(A)
GPCRdb(A)
GAL1 receptor
TM1
1x31 1.31x31 E32
TM2
2x60 2.61x60 Q92
2x63 2.64x63 V95
2x64 2.65x64 Y96
2x66 2.67x66 L98
TM3
3x29 3.29x29 H112
ECL2
45x50 45.50x50 C187
45x51 45.51x51 W188
45x52 45.52x52 E189
TM6
6x58 6.58x58 A270
TM7
7x31 7.32x31 F282
7x34 7.35x34 R285