PDB
7WQ3
Resolution
2.7 Å
Released
April 20, 2022
Receptor
GAL1
Class
A
Species
Homo sapiens
Ligand
galanin(1-13)amide
Function
Agonist
Reference
10.1038/S41467-022-29072-3

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Ligand Amino Acid Generic Number Segment Interaction Type
galanin(1-13)amide E32 1.31x31 TM1 polar (charge-assisted hydrogen bond)
galanin(1-13)amide Q92 2.61x60 TM2 polar (hydrogen bond)
galanin(1-13)amide Q92 2.61x60 TM2 Van der Waals
galanin(1-13)amide V95 2.64x63 TM2 Van der Waals
galanin(1-13)amide V95 2.64x63 TM2 polar (hydrogen bond with backbone)
galanin(1-13)amide Y96 2.65x64 TM2 Van der Waals
galanin(1-13)amide Y96 2.65x64 TM2 hydrophobic
galanin(1-13)amide L98 2.67x66 TM2 Van der Waals
galanin(1-13)amide L98 2.67x66 TM2 polar (hydrogen bond with backbone)
galanin(1-13)amide P99 ECL1 hydrophobic
galanin(1-13)amide P99 ECL1 Van der Waals
galanin(1-13)amide H112 3.29x29 TM3 Van der Waals
galanin(1-13)amide H112 3.29x29 TM3 polar (hydrogen bond)
galanin(1-13)amide F177 ECL2 Van der Waals
galanin(1-13)amide F177 ECL2 hydrophobic
galanin(1-13)amide R180 ECL2 Van der Waals
galanin(1-13)amide F186 ECL2 hydrophobic
galanin(1-13)amide F186 ECL2 Van der Waals
galanin(1-13)amide C187 45.50x50 ECL2 Van der Waals
galanin(1-13)amide W188 45.51x51 ECL2 polar (hydrogen bond)
galanin(1-13)amide E189 45.52x52 ECL2 Van der Waals
galanin(1-13)amide Q190 ECL2 Van der Waals
galanin(1-13)amide A270 6.58x58 TM6 hydrophobic
galanin(1-13)amide A270 6.58x58 TM6 Van der Waals
galanin(1-13)amide F275 ECL3 Van der Waals
galanin(1-13)amide F275 ECL3 hydrophobic
galanin(1-13)amide L277 ECL3 hydrophobic
galanin(1-13)amide L277 ECL3 Van der Waals
galanin(1-13)amide F282 7.32x31 TM7 hydrophobic
galanin(1-13)amide F282 7.32x31 TM7 Van der Waals
galanin(1-13)amide R285 7.35x34 TM7 Van der Waals

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ICL1 K P G K P R ICL1ECL1 P T W V L ECL1ICL2 S R R S S S L R ICL2ECL2 G L F H P R A S N Q T F C W E Q W P ECL2ICL3 K N M ICL3ECL3 V F P L ECL3N-term M E L A V G N L S E G N A S W P E P P A P E P G P L F G I N-termC-term C H I R K D S H L S D T K E S K S R I D T P P S T N C T H V C-term G V E N F V T L V V F G L I F A L G V L G N S L V I T V L A R S S T T N L F I L N L S I A D L A Y L L F C I P F Q A T V Y A L G A F I C K F I H Y F F T V S M L V S I F T L A A M S V D R Y V A I V H V S R N A L L G V G C I W A L S I A M A S P V A Y H Q D P R H K K A Y V V C T F V F G Y L L P L L L I C F C Y A K V L N H L H K K L S K K S E A S K K K T A Q T V L V V V V V F G I S W L P H H I I H L W A E F G T P A S F L F R I T A H C L A Y S N S S V N P I I Y A F L S E N Y K Q F R K A V F K
Helix box plot — Download: PNG | SVG S N G L V G L A F I L G F V V L T V F N 1 L N L S I A D L A Y L F L C I P F Q A T V 2 A A L T F I S V L M S V T F F Y H I F K 3 A L L G V G C I W A L S I A M A S P V 4 Y C F C I L L L P L L Y G F V F T C V V Y 5 L V V V V V F G I S W L P H H I I H L W 6 I P N V S S N S Y A L C H A T I R F L 7

GPCRdb(A)
GPCRdb(A)
GAL1 receptor
TM1
1x31 1.31x31 E32
TM2
2x60 2.61x60 Q92
2x63 2.64x63 V95
2x64 2.65x64 Y96
2x66 2.67x66 L98
TM3
3x29 3.29x29 H112
ECL2
45x50 45.50x50 C187
45x51 45.51x51 W188
45x52 45.52x52 E189
TM6
6x58 6.58x58 A270
TM7
7x31 7.32x31 F282
7x34 7.35x34 R285