PDB
7WQ4
Resolution
2.6 Å
Released
April 20, 2022
Receptor
GAL2
Class
A
Species
Homo sapiens
Ligand
galanin(1-13)amide
Function
Agonist
Reference
10.1038/S41467-022-29072-3

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Ligand Amino Acid Generic Number Segment Interaction Type
galanin(1-13)amide Q82 2.61x60 TM2 polar (hydrogen bond)
galanin(1-13)amide Q82 2.61x60 TM2 Van der Waals
galanin(1-13)amide I85 2.64x63 TM2 Van der Waals
galanin(1-13)amide I85 2.64x63 TM2 polar (hydrogen bond with backbone)
galanin(1-13)amide Y86 2.65x64 TM2 Van der Waals
galanin(1-13)amide L88 2.67x66 TM2 Van der Waals
galanin(1-13)amide L88 2.67x66 TM2 polar (hydrogen bond with backbone)
galanin(1-13)amide D89 ECL1 Van der Waals
galanin(1-13)amide G90 23.49x49 ECL1 polar (hydrogen bond with backbone)
galanin(1-13)amide G90 23.49x49 ECL1 Van der Waals
galanin(1-13)amide H102 3.29x29 TM3 Van der Waals
galanin(1-13)amide Y164 ECL2 hydrophobic
galanin(1-13)amide Y164 ECL2 Van der Waals
galanin(1-13)amide L169 ECL2 hydrophobic
galanin(1-13)amide L169 ECL2 Van der Waals
galanin(1-13)amide H176 45.51x51 ECL2 polar (hydrogen bond)
galanin(1-13)amide H176 45.51x51 ECL2 polar (hydrogen bond)
galanin(1-13)amide P177 45.52x52 ECL2 Van der Waals
galanin(1-13)amide P177 45.52x52 ECL2 hydrophobic
galanin(1-13)amide R184 5.35x36 TM5 polar (charge-assisted hydrogen bond)
galanin(1-13)amide F264 ECL3 Van der Waals
galanin(1-13)amide F264 ECL3 hydrophobic
galanin(1-13)amide L266 ECL3 hydrophobic
galanin(1-13)amide L266 ECL3 Van der Waals
galanin(1-13)amide T267 7.28x27 TM7 Van der Waals
galanin(1-13)amide T267 7.28x27 TM7 polar (hydrogen bond with backbone)
galanin(1-13)amide R268 7.29x28 TM7 Van der Waals
galanin(1-13)amide T270 7.31x30 TM7 Van der Waals
galanin(1-13)amide Y271 7.32x31 TM7 aromatic (edge-to-face)
galanin(1-13)amide Y271 7.32x31 TM7 Van der Waals
galanin(1-13)amide R274 7.35x34 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 G Q A V ICL1ECL1 D G W V F ECL1ICL2 P L H S R E L R ICL2ECL2 R Q S Q L A N L T V C H P A W ECL2ICL3 A A ICL3ECL3 Q F P L ECL3N-term M N V S G C P G A G N A S Q A G G G G G W H N-termC-term G L L G R A P G R A S G R V C A A A R G T H S G S V L E R E S S D L L H M S E A A G A L R P C P G A S Q P C I L E P C P G P S W Q G P K A G D S I L T V D V A C-term P E A V I V P L L F A L I F L V G T V G N T L V L A V L L R G S T T N L F I L N L G V A D L C F I L C C V P F Q A T I Y T L G S L L C K A V H F L I F L T M H A S S F T L A A V S L D R Y L A I R Y T P R N A L A A I G L I W G L S L L F S G P Y L S Y Y S A P R R R A M D I C T F V F S Y L L P V L V L G L T Y A R T L R Y L W R A V D P V G S G A R R A K R K V T R M I L I V A A L F C L C W M P H H A L I L C V W F G T R A T Y A L R I L S H L V S Y A N S C V N P I V Y A L V S K H F R T F R K G I C A
Helix box plot — Download: PNG | SVG T N G V T G V L F I L A F L L P V I V A 1 L N L G V A D L C F I C L C V P F Q A T I 2 A A L T F S S A H M T L F I L F H V A K 3 A L A A I G L I W G L S L L F S G P Y 4 Y T L G L V L V P L L Y S F V F T C I D M 5 L I V A A L F C L C W M P H H A L I L C 6 I P N V C S N A Y S V L H S L I R L A 7

GPCRdb(A)
GPCRdb(A)
GAL2 receptor
TM2
2x60 2.61x60 Q82
2x63 2.64x63 I85
2x64 2.65x64 Y86
2x66 2.67x66 L88
ECL1
23x49 23.49x49 G90
TM3
3x29 3.29x29 H102
ECL2
45x51 45.51x51 H176
45x52 45.52x52 P177
TM5
5x36 5.35x36 R184
TM7
7x27 7.28x27 T267
7x28 7.29x28 R268
7x30 7.31x30 T270
7x31 7.32x31 Y271
7x34 7.35x34 R274