Structure information

ADGRG2

PROTEIN CLASS

Class B2 (Adhesion)

PDB CODE

7WUI

SPECIES

Mus musculus

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-022-04590-8

PUBLICATION DATE

April 27, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
IP15 L620 1.39x39 TM1 hydrophobic
IP15 T621 1.40x40 TM1 polar (hydrogen bond)
IP15 T621 1.40x40 TM1 polar (hydrogen bond)
IP15 T624 1.43x43 TM1 polar (hydrogen bond)
IP15 Y625 1.44x44 TM1 Van der Waals
IP15 L667 2.60x60 TM2 Van der Waals
IP15 N668 2.61x61 TM2 Van der Waals
IP15 F671 2.64x64 TM2 hydrophobic
IP15 F671 2.64x64 TM2 Van der Waals
IP15 L697 3.40x40 TM3 hydrophobic
IP15 L697 3.40x40 TM3 Van der Waals
IP15 F701 3.44x44 TM3 hydrophobic
IP15 F701 3.44x44 TM3 Van der Waals
IP15 D768 ECL2 Van der Waals
IP15 F769 ECL2 hydrophobic
IP15 F769 ECL2 Van der Waals
IP15 W771 45.51x51 ECL2 polar (hydrogen bond)
IP15 W771 45.51x51 ECL2 Van der Waals
IP15 I772 45.52x52 ECL2 polar (hydrogen bond with backbone)
IP15 I772 45.52x52 ECL2 Van der Waals
IP15 S774 ECL2 polar (hydrogen bond with backbone)
IP15 S774 ECL2 Van der Waals
IP15 N775 5.32x33 TM5 polar (hydrogen bond with backbone)
IP15 N775 5.32x33 TM5 polar (hydrogen bond)
IP15 F778 5.35x36 TM5 Van der Waals
IP15 F778 5.35x36 TM5 hydrophobic
IP15 Y779 5.36x37 TM5 polar (hydrogen bond)
IP15 Y779 5.36x37 TM5 Van der Waals
IP15 V782 5.39x39 TM5 Van der Waals
IP15 V783 5.40x40 TM5 hydrophobic
IP15 V783 5.40x40 TM5 Van der Waals
IP15 F786 5.43x43 TM5 Van der Waals
IP15 F786 5.43x43 TM5 hydrophobic
IP15 W838 6.53x53 TM6 Van der Waals
IP15 W838 6.53x53 TM6 hydrophobic
IP15 A841 6.56x56 TM6 hydrophobic
IP15 A841 6.56x56 TM6 Van der Waals
IP15 F842 6.57x57 TM6 Van der Waals
IP15 F842 6.57x57 TM6 hydrophobic
IP15 W845 6.60x60 TM6 polar (hydrogen bond)
IP15 W845 6.60x60 TM6 polar (hydrogen bond)
IP15 F856 7.42x41 TM7 hydrophobic
IP15 F856 7.42x41 TM7 Van der Waals
IP15 A857 7.43x42 TM7 Van der Waals
IP15 N860 7.46x45 TM7 Van der Waals
IP15 T861 7.47x46 TM7 Van der Waals

Ligands

IP15

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Residue Diagrams

S L F I S S L G C G I Y T I F T L A M M 1 I Q L C A A L L L L N L I F L L D S W I 2 L G M W T F S V L L F Y H L F V A V A I 3 Y I L K F C I G V W G I P A V V V S I V L 4 F M S V N L L F I V C F Y G V V T I Y F V 5 A G L T F L L G I T W G F A F F A W G 6 I F I F F G Q L T N F I A F L Y M F T 7
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ICL1 E K I R R ICL1ECL1 N ECL1ICL2 V F N T Y I R ICL2ECL2 P D N Y G I G S Y G K F P N G T P D D F C W I N S ECL2ICL3 Q L G A Q R K ICL3ECL3 P V N ECL3N-term M L F S G G Q Y S P V G R P E E V L L I Y K I F L V I I C F H V I L V T S L K E N G N S S L L S P S A E S S L V S L I P Y S N G T P D A A S E V L S T L N K T E K S K I T I V K T F N A S G V K S Q R N I C N L S S L C N D S V F F R G E I V F Q H D E D H N V T Q N Q D T A N G T F A G V L S L S E L K R S E L N K T L Q T L S E T Y F I V C A T A E A Q S T V N C T F T V K L N E T M N V C A M M V T F Q T V Q I R P M E Q C C C S P R T P C P S S P E E L E K L Q C E L Q D P I V C L A D Q P H G P P L S S S S K P V V P Q A T I I S H V A S D F S L A E P L D H A L M T P S T P S L T Q E S N L P S P Q P T I P L A S S P A T D L P V Q S V V V S S L P Q T D L S H T L S P V Q S S I P S P T T P A P S V P T E L V T I S T P P G E T V V N T S T V S D L E A Q V S Q M E K A L S L G S L E P N L A G E M V N R V S K L L H S P P A L L A P L A Q R L L K V V D A I G L Q L N F S S T T I S L T S P S L A L A V I R V N A S N F N T T T F A A Q D P T N L Q V S L E T P P P E N S I G A I T L P S S L M N N L P A N D V E L A S R I Q F N F F E T P A L F Q D P S L E N L T L I S Y V I S S S V T N M T I K N L T R N V T V A L K H I N P S P D D L T V K C V F W D L G R N G G K G G W S S D G C S V K D K R M N E T I C T C S H L T S F G I L L D L S R T S L P N-termC-term R L A E N S D W S K T A T N G L K K Q T V N Q G V S S S S N S L Q S S C N S T N S T T L L V N S D C S V H A S G N G N A S T E R N G V S F S V Q N G D V C L H D L T G K Q H M F S D K E D S C N G K S R I A L R R T S K R G S L H F I E Q M C-term P S Q M M A L T F I T Y I G C G L S S I F L S V T L V T Y I A F D Y P S K I L I Q L C A A L L L L N L I F L L D S W I A L Y T R G F C I A V A V F L H Y F L L V S F T W M G L E A F H M Y L A L V K K Y I L K F C I V G W G I P A V V V S I V L T I S N V V F Y I T V V G Y F C V I F L L N V S M F I V V L V Q L C R I K K K K T S I Q D L R S I A G L T F L L G I T W G F A F F A W G V T F M Y L F A I F N T L Q G F F I F I F Y C A A K E N V R R Y K L R K Q W L C C G
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Residue Table


GPCRdb(A)
GPCRdb(B)
ADGRG2
TM1
1x35 1.39x39 L620
1x36 1.40x40 T621
1x39 1.43x43 T624
1x40 1.44x44 Y625
TM2
2x53 2.60x60 L667
2x54 2.61x61 N668
2x57 2.64x64 F671
TM3
3x36 3.40x40 L697
3x40 3.44x44 F701
ECL2
45x51 45.51x51 W771
45x52 45.52x52 I772
TM5
5x37 5.32x33 N775
5x40 5.35x36 F778
5x41 5.36x37 Y779
5x43 5.39x39 V782
5x44 5.40x40 V783
5x47 5.43x43 F786
TM6
6x48 6.53x53 W838
6x51 6.56x56 A841
6x52 6.57x57 F842
6x55 6.60x60 W845
TM7
7x37 7.42x41 F856
7x38 7.43x42 A857
7x41 7.46x45 N860
7x42 7.47x46 T861