Structure information

FPR2/ALX

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7WVW

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-29361-X

PUBLICATION DATE

April 13, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU L81 2.60x60 TM2 hydrophobic
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU V105 3.32x32 TM3 hydrophobic
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU D106 3.33x33 TM3 polar (charge-assisted hydrogen bond)
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU L109 3.36x36 TM3 hydrophobic
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU L109 3.36x36 TM3 Van der Waals
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU F110 3.37x37 TM3 hydrophobic
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU F110 3.37x37 TM3 Van der Waals
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU Y175 ECL2 Van der Waals
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU Y175 ECL2 hydrophobic
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU T177 45.51x51 ECL2 Van der Waals
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU T177 45.51x51 ECL2 polar (hydrogen bond)
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU F178 45.52x52 ECL2 Van der Waals
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU F178 45.52x52 ECL2 hydrophobic
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU L198 5.35x36 TM5 Van der Waals
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU L198 5.35x36 TM5 hydrophobic
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU R201 5.38x39 TM5 polar (charge-assisted hydrogen bond)
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU R205 5.42x43 TM5 polar (charge-assisted hydrogen bond)
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU G209 5.46x461 TM5 Van der Waals
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU W254 6.48x48 TM6 Van der Waals
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU F257 6.51x51 TM6 Van der Waals
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU F257 6.51x51 TM6 hydrophobic
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU Q258 6.52x52 TM6 Van der Waals
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU L272 ECL3 hydrophobic
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU L272 ECL3 Van der Waals
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU V284 7.35x34 TM7 hydrophobic
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU V284 7.35x34 TM7 Van der Waals
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU F292 7.43x42 TM7 Van der Waals
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU F292 7.43x42 TM7 hydrophobic

Ligands

FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU

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Residue Diagrams

G N G L V G L V F T V G L V V L P L I R 1 L N L A L A D F S F T A T L P F L I V S 2 F G I L F V S G F L N I D V V I H I L K 3 A M K V I V G P W I L A L V L T L P V 4 Y C I A V I S M P L S F G I V F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F F A L S S T P N V L I 7
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ICL1 T R ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V T I P N G D T Y C T F N F A S W G G ECL2ICL3 M I K S ICL3ECL3 L K E M L F Y G K ECL3N-term M E T N F S T P L N E Y E E V S Y E N-termC-term P T S L E R A L S E D S A P T N D T A A N S A S P P A E T E L Q A M C-term S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H T V S L A M K V I V G P W I L A L V L T L P V F L F L T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D L I H F R E R S L
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Residue Table


GPCRdb(A)
GPCRdb(A)
FPR2/ALX
TM2
2x60 2.60x60 L81
TM3
3x32 3.32x32 V105
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
ECL2
45x51 45.51x51 T177
45x52 45.52x52 F178
TM5
5x36 5.35x36 L198
5x39 5.38x39 R201
5x43 5.42x43 R205
5x461 5.46x461 G209
TM6
6x48 6.48x48 W254
6x51 6.51x51 F257
6x52 6.52x52 Q258
TM7
7x34 7.35x34 V284
7x42 7.43x42 F292