Structure information

FPR2/ALX

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7WVY

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-29361-X

PUBLICATION DATE

April 13, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Amyloid beta-Peptide (1-42) M85 2.64x64 TM2 hydrophobic
Amyloid beta-Peptide (1-42) D106 3.33x33 TM3 polar (hydrogen bond with backbone)
Amyloid beta-Peptide (1-42) D106 3.33x33 TM3 Van der Waals
Amyloid beta-Peptide (1-42) L109 3.36x36 TM3 Van der Waals
Amyloid beta-Peptide (1-42) L109 3.36x36 TM3 hydrophobic
Amyloid beta-Peptide (1-42) F110 3.37x37 TM3 Van der Waals
Amyloid beta-Peptide (1-42) F110 3.37x37 TM3 polar (hydrogen bond with backbone)
Amyloid beta-Peptide (1-42) V113 3.40x40 TM3 hydrophobic
Amyloid beta-Peptide (1-42) V113 3.40x40 TM3 Van der Waals
Amyloid beta-Peptide (1-42) L164 ECL2 Van der Waals
Amyloid beta-Peptide (1-42) F178 45.52x52 ECL2 Van der Waals
Amyloid beta-Peptide (1-42) F178 45.52x52 ECL2 polar (hydrogen bond with backbone)
Amyloid beta-Peptide (1-42) N179 ECL2 Van der Waals
Amyloid beta-Peptide (1-42) F180 ECL2 hydrophobic
Amyloid beta-Peptide (1-42) F180 ECL2 Van der Waals
Amyloid beta-Peptide (1-42) R201 5.38x39 TM5 polar (charge-assisted hydrogen bond)
Amyloid beta-Peptide (1-42) R205 5.42x43 TM5 polar (charge-assisted hydrogen bond)
Amyloid beta-Peptide (1-42) G209 5.46x461 TM5 polar (hydrogen bond with backbone)
Amyloid beta-Peptide (1-42) G209 5.46x461 TM5 Van der Waals
Amyloid beta-Peptide (1-42) W254 6.48x48 TM6 Van der Waals
Amyloid beta-Peptide (1-42) F257 6.51x51 TM6 hydrophobic
Amyloid beta-Peptide (1-42) F257 6.51x51 TM6 Van der Waals
Amyloid beta-Peptide (1-42) Q258 6.52x52 TM6 polar (hydrogen bond)
Amyloid beta-Peptide (1-42) Q258 6.52x52 TM6 Van der Waals
Amyloid beta-Peptide (1-42) A261 6.55x55 TM6 Van der Waals
Amyloid beta-Peptide (1-42) A261 6.55x55 TM6 hydrophobic
Amyloid beta-Peptide (1-42) L272 ECL3 Van der Waals
Amyloid beta-Peptide (1-42) L272 ECL3 hydrophobic
Amyloid beta-Peptide (1-42) D281 7.32x31 TM7 Van der Waals
Amyloid beta-Peptide (1-42) V284 7.35x34 TM7 Van der Waals
Amyloid beta-Peptide (1-42) V284 7.35x34 TM7 hydrophobic
Amyloid beta-Peptide (1-42) N285 7.36x35 TM7 Van der Waals
Amyloid beta-Peptide (1-42) N285 7.36x35 TM7 polar (hydrogen bond)
Amyloid beta-Peptide (1-42) S288 7.39x38 TM7 Van der Waals

Ligands

Amyloid beta-Peptide (1-42)

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Residue Diagrams

G N G L V G L V F T V G L V V L P L I R 1 L N L A L A D F S F T A T L P F L I V S 2 F G I L F V S G F L N I D V V I H I L K 3 A M K V I V G P W I L A L V L T L P V 4 Y C I A V I S M P L S F G I V F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F F A L S S T P N V L I 7
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ICL1 T R ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V T I P N G D T Y C T F N F A S W G G ECL2ICL3 M I K S ICL3ECL3 L K E M L F Y G K ECL3N-term M E T N F S T P L N E Y E E V S Y E N-termC-term P T S L E R A L S E D S A P T N D T A A N S A S P P A E T E L Q A M C-term S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H T V S L A M K V I V G P W I L A L V L T L P V F L F L T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D L I H F R E R S L
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Residue Table


GPCRdb(A)
GPCRdb(A)
FPR2/ALX
TM2
2x64 2.64x64 M85
TM3
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
3x40 3.40x40 V113
ECL2
45x52 45.52x52 F178
TM5
5x39 5.38x39 R201
5x43 5.42x43 R205
5x461 5.46x461 G209
TM6
6x48 6.48x48 W254
6x51 6.51x51 F257
6x52 6.52x52 Q258
6x55 6.55x55 A261
TM7
7x31 7.32x31 D281
7x34 7.35x34 V284
7x35 7.36x35 N285
7x38 7.39x38 S288