Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7X8R

SPECIES

Homo sapiens

RESOLUTION

2.610

PREFERRED CHAIN

R

PUBLICATION DATE

June 29, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL2158411 W33 N-term aromatic (face-to-edge)
CHEMBL2158411 Q140 1.35x35 TM1 polar (hydrogen bond with backbone)
CHEMBL2158411 Q140 1.35x35 TM1 Van der Waals
CHEMBL2158411 L141 1.36x36 TM1 hydrophobic
CHEMBL2158411 L141 1.36x36 TM1 Van der Waals
CHEMBL2158411 L144 1.39x39 TM1 Van der Waals
CHEMBL2158411 K197 2.67x67 TM2 Van der Waals
CHEMBL2158411 L201 2.71x71 TM2 Van der Waals
CHEMBL2158411 L201 2.71x71 TM2 hydrophobic
CHEMBL2158411 C226 3.29x29 TM3 Van der Waals
CHEMBL2158411 V229 3.32x32 TM3 Van der Waals
CHEMBL2158411 V229 3.32x32 TM3 hydrophobic
CHEMBL2158411 F230 3.33x33 TM3 hydrophobic
CHEMBL2158411 F230 3.33x33 TM3 Van der Waals
CHEMBL2158411 T298 45.52x52 ECL2 Van der Waals
CHEMBL2158411 R299 ECL2 polar (charge-assisted hydrogen bond)
CHEMBL2158411 F381 7.36x35 TM7 hydrophobic
CHEMBL2158411 F381 7.36x35 TM7 Van der Waals
CHEMBL2158411 L388 7.43x42 TM7 Van der Waals

Ligands

CHEMBL2158411

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x31 1.35x35 Q140
1x32 1.36x36 L141
1x35 1.39x39 L144
TM2
2x60 2.67x67 K197
2x64 2.71x71 L201
TM3
3x25 3.29x29 C226
3x28 3.32x32 V229
3x29 3.33x33 F230
ECL2
45x52 45.52x52 T298
TM7
7x31 7.36x35 F381
7x38 7.43x42 L388