Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7X8S

SPECIES

Homo sapiens

RESOLUTION

3.090

PREFERRED CHAIN

R

REFERENCE

10.1073/PNAS.2200155119

PUBLICATION DATE

June 29, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
WB4-24 W33 N-term aromatic (face-to-edge)
WB4-24 Q140 1.35x35 TM1 polar (hydrogen bond with backbone)
WB4-24 Q140 1.35x35 TM1 Van der Waals
WB4-24 L141 1.36x36 TM1 hydrophobic
WB4-24 L141 1.36x36 TM1 Van der Waals
WB4-24 L144 1.39x39 TM1 Van der Waals
WB4-24 L144 1.39x39 TM1 hydrophobic
WB4-24 Y145 1.40x40 TM1 aromatic (face-to-edge)
WB4-24 Y145 1.40x40 TM1 Van der Waals
WB4-24 Y152 1.47x47 TM1 Van der Waals
WB4-24 V194 2.64x64 TM2 hydrophobic
WB4-24 K197 2.67x67 TM2 Van der Waals
WB4-24 D198 2.68x68 TM2 Van der Waals
WB4-24 L201 2.71x71 TM2 hydrophobic
WB4-24 L201 2.71x71 TM2 Van der Waals
WB4-24 K202 2.72x72 TM2 Van der Waals
WB4-24 C226 3.29x29 TM3 Van der Waals
WB4-24 V229 3.32x32 TM3 hydrophobic
WB4-24 V229 3.32x32 TM3 Van der Waals
WB4-24 F230 3.33x33 TM3 hydrophobic
WB4-24 T298 45.52x52 ECL2 Van der Waals
WB4-24 T298 45.52x52 ECL2 polar (hydrogen bond)
WB4-24 R299 ECL2 Van der Waals
WB4-24 R380 7.35x34 TM7 polar (charge-assisted hydrogen bond)
WB4-24 F381 7.36x35 TM7 Van der Waals
WB4-24 F381 7.36x35 TM7 hydrophobic
WB4-24 L384 7.39x38 TM7 Van der Waals
WB4-24 L384 7.39x38 TM7 hydrophobic
WB4-24 L388 7.43x42 TM7 Van der Waals
WB4-24 L388 7.43x42 TM7 hydrophobic

Ligands

WB4-24

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x31 1.35x35 Q140
1x32 1.36x36 L141
1x35 1.39x39 L144
1x36 1.40x40 Y145
1x43 1.47x47 Y152
TM2
2x57 2.64x64 V194
2x60 2.67x67 K197
2x61 2.68x68 D198
2x64 2.71x71 L201
2x65 2.72x72 K202
TM3
3x25 3.29x29 C226
3x28 3.32x32 V229
3x29 3.33x33 F230
ECL2
45x52 45.52x52 T298
TM7
7x30 7.35x34 R380
7x31 7.36x35 F381
7x34 7.39x38 L384
7x38 7.43x42 L388