Structure information

SST2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XAV

SPECIES

Homo sapiens

RESOLUTION

2.870

PREFERRED CHAIN

A

REFERENCE

10.1038/S41421-022-00405-2

PUBLICATION DATE

Aug. 31, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
lanreotide F127 3.37x37 TM3 hydrophobic
lanreotide T194 45.51x51 ECL2 Van der Waals
lanreotide T194 45.51x51 ECL2 polar (hydrogen bond)
lanreotide Y205 ECL2 Van der Waals
lanreotide Y205 ECL2 polar (hydrogen bond with backbone)
lanreotide T206 ECL2 Van der Waals
lanreotide F208 5.38x39 TM5 polar (hydrogen bond with backbone)
lanreotide F208 5.38x39 TM5 Van der Waals
lanreotide I209 5.39x40 TM5 hydrophobic
lanreotide I209 5.39x40 TM5 Van der Waals
lanreotide T212 5.42x43 TM5 Van der Waals
lanreotide F272 6.51x51 TM6 hydrophobic
lanreotide F272 6.51x51 TM6 Van der Waals
lanreotide N276 6.55x55 TM6 Van der Waals
lanreotide S279 6.58x58 TM6 Van der Waals
lanreotide S279 6.58x58 TM6 polar (hydrogen bond)
lanreotide F294 7.35x34 TM7 hydrophobic
lanreotide F294 7.35x34 TM7 Van der Waals
lanreotide V298 7.39x38 TM7 hydrophobic
lanreotide V298 7.39x38 TM7 Van der Waals
lanreotide Y302 7.43x42 TM7 Van der Waals

Ligands

lanreotide

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Residue Diagrams

T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7
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ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM3
3x37 3.37x37 F127
ECL2
45x51 45.51x51 T194
TM5
5x39 5.38x39 F208
5x40 5.39x40 I209
5x43 5.42x43 T212
TM6
6x51 6.51x51 F272
6x55 6.55x55 N276
6x58 6.58x58 S279
TM7
7x34 7.35x34 F294
7x38 7.39x38 V298
7x42 7.43x42 Y302